{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:56:39Z","timestamp":1771664199892,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","award":["Scholar Award 523803"],"award-info":[{"award-number":["Scholar Award 523803"]}],"id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30 ES010126"],"award-info":[{"award-number":["P30 ES010126"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["F31 CA260787"],"award-info":[{"award-number":["F31 CA260787"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA204258"],"award-info":[{"award-number":["R01 CA204258"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA211093"],"award-info":[{"award-number":["R01 CA211093"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32 CA057726"],"award-info":[{"award-number":["T32 CA057726"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fertility preservation (FP) may be underused after cancer diagnosis because of uncertainty around delays to cancer treatment and subsequent reproductive success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women aged 15 to 39\u00a0years diagnosed with cancer between 2004 and 2015 were identified from the North Carolina Central Cancer Registry. Use of assisted reproductive technology (ART) after cancer diagnosis between 2004 and 2018 (including FP) was assessed through linkage to the Society for Assisted Reproductive Technology. Linear regression was used to examine time to cancer treatment among women who did (<jats:italic>n<\/jats:italic>\u00a0=\u00a095) or did not (<jats:italic>n<\/jats:italic>\u00a0=\u00a0469) use FP. Modified Poisson regression was used to estimate risk ratios (RRs) and 95% CIs for pregnancy and birth based on timing of ART initiation relative to cancer treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a018 initiated before treatment for FP vs <jats:italic>n<\/jats:italic>\u00a0=\u00a026 initiated after treatment without FP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median time to cancer treatment was 9 to 33\u00a0days longer among women who used FP compared with women who did not, matched on clinical factors. Women who initiated ART before cancer treatment may be more likely to have a live birth given pregnancy compared with women who initiated ART after cancer treatment (age\u2010adjusted RR, 1.47; 95% CI, 0.98\u20102.23), though this may be affected by the more frequent use of gestational carriers in the former group (47% vs 20% of transfer cycles, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FP delayed gonadotoxic cancer treatment by up to 4.5\u00a0weeks, a delay that would not be expected to alter prognosis for many women. Further study of the use of gestational carriers in cancer populations is warranted to better understand its effect on reproductive outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34520","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:50:47Z","timestamp":1667263847000},"page":"307-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Time to cancer treatment and reproductive outcomes after fertility preservation among adolescent and young adult women with cancer"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-1266","authenticated-orcid":false,"given":"Clare","family":"Meernik","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health  Chapel Hill North Carolina USA"},{"name":"Department of Population Health Sciences Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie M.","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Baggett","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health  Chapel Hill North Carolina USA"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ally","family":"Wardell","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina at Chapel Hill Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-7543","authenticated-orcid":false,"given":"Xi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-332X","authenticated-orcid":false,"given":"Kathryn J.","family":"Ruddy","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Wantman","sequence":"additional","affiliation":[{"name":"Redshift Technologies, Inc  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Luke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology, and Reproductive Biology College of Human Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer E.","family":"Mersereau","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina at Chapel Hill Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew F.","family":"Olshan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-3853","authenticated-orcid":false,"given":"Andrew B.","family":"Smitherman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0972-1560","authenticated-orcid":false,"given":"Hazel B.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21585"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29181"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29328"},{"key":"e_1_2_9_6_1","unstructured":"Livestrong Foundation.Livestrong Brief: Suvivors\u2019 Experiences with Fertility;2013. Accessed March 14 2019.http:\/\/www.LIVEstronG.org\/fertility"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010012\u20100227\u20109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2012.664257"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010020\u201006031\u20104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215419"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.10.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010007\u20100019\u20109"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.14511"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.03.010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010017\u20104288\u20103"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.08.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14466"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.10.029"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.8700"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen\u20102018\u2010000459"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2019.0124"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex276"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010020\u201005858\u20101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010021\u201005985\u20100"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33601"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.013"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100545\u20107"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_208301"},{"key":"e_1_2_9_30_1","unstructured":"Centers for Disease Control and Prevention.Archived ART Reports and Spreadsheets. Accessed September 12 2021.https:\/\/www.cdc.gov\/art\/reports\/archive.html"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.101652"},{"key":"e_1_2_9_32_1","unstructured":"Economic Research Servce United States Department of Agriculture.Rural\u2010Urban Commuting Area Codes. Accessed December 14 2020.https:\/\/www.ers.usda.gov\/data\u2010products\/rural\u2010urban\u2010commuting\u2010area\u2010codes\/"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010013\u20100310\u20101"},{"key":"e_1_2_9_34_1","volume-title":"Regression Methods in Biostatistics","author":"Vittinghoff E","year":"2005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010017\u20102248\u20101"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6344"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280220958735"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102020\u2010001328"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.03.029"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.011"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.5748"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.08.030"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010019\u201001462\u20105"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2017.1287433"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12054"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.5957"},{"key":"e_1_2_9_48_1","unstructured":"United States Census Bureau.Geographical Mobility: 2005 to 2010;2012. Accessed July 4 2022.https:\/\/www.census.gov\/library\/publications\/2012\/demo\/p20\u2010567.html"},{"key":"e_1_2_9_49_1","unstructured":"United States Census Bureau.Geographical Mobility: 2010 to 2015;2017. Accessed July 4 2022.https:\/\/www.census.gov\/data\/tables\/2015\/demo\/geographic\u2010mobility\/cps\u20102015\u20105yr.html"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.34520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:43:01Z","timestamp":1760276581000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.34520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,31]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1,15]]}},"alternative-id":["10.1002\/cncr.34520"],"URL":"https:\/\/doi.org\/10.1002\/cncr.34520","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,31]]},"assertion":[{"value":"2022-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}