{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:53:42Z","timestamp":1760316822274,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal treatment strategy for refractory or relapse (R\/R) indolent non\u2010Hodgkin lymphoma (iNHL) has not been fully identified. This study aims to investigate the efficacy and tolerance of bendamustine hydrochloride developed in native Chinese corporation in the treatment of patients with R\/R iNHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 101 patients from 19 centers were enrolled in this study from July 2016 to February 2019. Bendamustine hydrochloride (120\u00a0mg\/m<jats:sup>2<\/jats:sup>) was given on days 1 and 2 of each 21\u2010day treatment cycle for six planned cycles or up to eight cycles if tolerated. Parameters of efficacy and safety were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the patients was 53.44 (range, 24.4\u201374.6) years old. A total of 56 (55.44%) patients completed at least six treatment cycles, and the relative dose intensity was 93.78%. The overall response rate was 72.28%, and the median duration of response was 15.84\u00a0months (95% confidence interval [CI], 13.77\u201327.48\u00a0months). Median progression\u2010free survival was 16.52\u00a0months (95% CI, 14.72\u201323.41\u00a0months), and the median overall survival was not reached. Grade 3 or 4 hematologic toxicities included neutropenia (77.22%), thrombocytopenia (29.70%), and anemia (15.84%). The most frequent nonhematologic adverse events (any grade) included nausea, vomiting, fatigue, fever, decreased appetite, and weight loss. Seven patients died during the trial, and four cases may be related to the investigational drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study reveals that bendamustine hydrochloride is a feasible treatment option for the indolent B\u2010cell non\u2010Hodgkin lymphoma patient who has not remitted or relapsed after treatment with rituximab. All adverse events were predictable and manageable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34544","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T05:05:37Z","timestamp":1671599137000},"page":"551-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bendamustine in the treatment of patients with indolent non\u2010Hodgkin lymphoma refractory or relapse to rituximab treatment: An open\u2010label, single\u2010agent, multicenter study in China"],"prefix":"10.1002","volume":"129","author":[{"given":"Yan","family":"Gao","sequence":"first","affiliation":[{"name":"Sun Yat\u2010Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine  Guangzhou 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