{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:20:45Z","timestamp":1792120845526,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chimeric antigen receptor (CAR) T\u2010cell is potentially curative therapy for patients with hematologic malignancies but can cause life\u2010threatening toxicities. Data on perceptions of prognosis and psychological distress are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors conducted a cross\u2010sectional study of patients receiving CAR\u2010T. Before hospitalization for CAR\u2010T, patients completed assessments of quality of life (QOL) (Functional Assessment of Cancer Therapy\u2010General), anxiety and depression symptoms (Hospital Anxiety and Depression Scale) and post\u2010traumatic stress disorder symptoms (Post\u2010Traumatic Stress Checklist). Patients also completed the Prognostic Awareness Impact Scale (PAIS), which measures three domains: cognitive understanding of prognosis, emotional coping with prognosis, and adaptive response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 71.8% (102 of 142) of eligible patients were enrolled. A total of 34% of patients reported that their oncologist said their cancer is curable and 64% reported there was <jats:styled-content>&gt;<\/jats:styled-content>50% chance of cure. Overall, 26%, 30%, and 21% of patients reported clinically significant depression, anxiety, and posttraumatic stress disorder (PTSD) symptoms, respectively. We found no association between patients' cognitive understanding of prognosis and QOL or mood. Higher emotional coping with prognosis was associated with better QOL (\u0392\u00a0=\u00a00.72; SE\u00a0=\u00a00.10; <jats:italic>p<\/jats:italic> = &lt;.001) and lower depression (\u0392\u00a0=\u00a0\u22120.17; SE\u00a0=\u00a00.02; <jats:italic>p<\/jats:italic> = &lt;.001), anxiety (\u0392\u00a0=\u00a0\u22120.21; SE\u00a0=\u00a00.02; <jats:italic>p<\/jats:italic>\u00a0= &lt;.001), and PTSD (\u0392\u00a0=\u00a0\u22120.43; SE\u00a0=\u00a00.06; <jats:italic>p<\/jats:italic> = &lt;.001) symptoms. Higher adaptive response was associated with better QOL (\u0392\u00a0=\u00a00.19; SE\u00a0=\u00a00.09; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.028) and lower depression (\u0392\u00a0=\u00a0\u22120.05; SE\u00a0=\u00a00.02; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.023), anxiety (\u0392\u00a0=\u00a0\u22120.09; SE\u00a0=\u00a00.02; <jats:italic>p<\/jats:italic> = &lt;.001), and PTSD (\u0392\u00a0=\u00a0\u22120.19; SE\u00a0=\u00a00.05; <jats:italic>p<\/jats:italic> = &lt;.001) symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients undergoing CAR\u2010T report overly optimistic perception of their prognosis and have high rates of psychological distress. Higher emotional coping with prognosis and adaptive response were associated with better QOL and less psychological distress, underscoring the need to develop interventions to promote coping with this treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain language summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Patients undergoing chimeric antigen receptor T\u2010cell therapy experience report overly optimistic perceptions of their prognosis and have high rates of psychological distress.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Notably, higher emotional coping with prognosis and adaptive response were associated with better quality of life and less psychological distress.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34557","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T05:20:05Z","timestamp":1669958405000},"page":"441-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Perception of prognosis, quality of life, and distress in patients receiving chimeric antigen receptor T\u2010cell therapy"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0163-2061","authenticated-orcid":false,"given":"Tejaswini M.","family":"Dhawale","sequence":"first","affiliation":[{"name":"Cancer Center Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3943-6608","authenticated-orcid":false,"given":"P. 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