{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:22:36Z","timestamp":1777519356388,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA078938"],"award-info":[{"award-number":["R01CA078938"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA213140"],"award-info":[{"award-number":["U01CA213140"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A comprehensive assessment of morbidity after allogeneic bone marrow transplantation (BMT) performed in childhood remains understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven hundred eighty\u2010nine allogeneic BMT recipients who had survived \u22652\u00a0years after BMT performed between 1974 and 2014 at age &lt;22\u00a0years and 690 siblings completed a 255\u2010item survey self\u2010reporting sociodemographics and chronic health conditions. A severity score (grade 3 [severe], 4 [life\u2010threatening], or 5 [fatal]) was assigned to the conditions using Common Terminology Criteria for Adverse Events, version 5.0. For the BMT cohort, the cumulative incidence of chronic health conditions was calculated as a function of time from BMT. Proportional subdistribution hazards models were used to determine predictors of grade 3\u20135 conditions. Logistic regression was used to estimate the risk of grade 3\u20134 conditions in BMT recipients who were alive at the time of this study compared with siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age at transplantation was 11.3\u00a0years (range, 0.4\u201322.0 years), and the median length of follow\u2010up was 11.7\u00a0years (range, 2.0\u201345.3 years). The most prevalent primary diagnoses were acute lymphoblastic leukemia (30.7%), and acute myeloid leukemia\/myelodysplastic syndrome (26.9%). At age 35\u00a0years, the cumulative incidence of a grade 3\u20134 condition was 53.8% (95% CI, 46.7%\u201360.3%). The adjusted odds ratio of a grade 3\u20134 condition was 15.1 in survivors (95% CI, 9.5\u201324.0) compared with siblings. The risk of a grade 3\u20135 condition increased with age at BMT (hazard ratio [HR], 1.03; 95% CI, 1.01\u20131.05) and was higher among females (HR, 1.27; 95% CI, 1.02\u20131.59), patients who received total body irradiation (HR, 1.71; 95% CI, 1.27\u20132.31), and those reporting chronic graft\u2010versus\u2010host disease (HR, 1.38; 95% CI, 1.09\u20131.74).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Two\u2010year survivors of allogeneic BMT in childhood have an increased risk of grade 3\u20134 chronic health conditions compared with siblings, suggesting the need for long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34575","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T05:30:00Z","timestamp":1670563800000},"page":"624-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Severe, life\u2010threatening, and fatal chronic health conditions after allogeneic blood or marrow transplantation in childhood"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-8148","authenticated-orcid":false,"given":"Anna S\u00e4llfors","family":"Holmqvist","sequence":"first","affiliation":[{"name":"Childhood Cancer Center, Skane University Hospital, Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Hageman","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Landier","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liton F.","family":"Francisco","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1972-6015","authenticated-orcid":false,"given":"Elizabeth Schlichting","family":"Ross","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora A.","family":"Balas","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0662-5699","authenticated-orcid":false,"given":"Alysia","family":"Bosworth","sequence":"additional","affiliation":[{"name":"Population Science City of Hope  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hok Sreng","family":"Te","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Transplantation University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick D.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology and Bone Marrow Transplantation University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology City of Hope  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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