{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:47:46Z","timestamp":1790880466350,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"publisher","award":["59101"],"award-info":[{"award-number":["59101"]}],"id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000982","name":"Conquer Cancer Foundation","doi-asserted-by":"publisher","award":["59354"],"award-info":[{"award-number":["59354"]}],"id":[{"id":"10.13039\/100000982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA138292"],"award-info":[{"award-number":["P30CA138292"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Risk factors for progression to advanced\u2010stage mycosis fungoides (MF) are poorly defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors performed a single\u2010center, retrospective cohort study among patients with MF at an academic medical center from 1990 to 2020 to identify clinical variables associated with progression to advanced\u2010stage MF (stage IIB\u2013IVB), and 388 patients who had a clinicopathologic diagnosis of early stage (IA\u2013IIA) MF were identified from their cutaneous lymphoma database. Baseline clinical characteristics, laboratory values, imaging, and blood flow cytometry or T\u2010cell receptor gene rearrangement (TCR) data were collected. Logistic regression was used to assess risk factors associated with progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 93 of 388 patients (24.0%) progressed to advanced stage. Patients who progressed had an increased risk of death (hazard ratio, 4.50; 95% CI, 2.89\u20137.00; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Progression was associated with a higher overall stage at diagnosis, tumor stage, lymph node stage, low\u2010level blood involvement, as measured with TCR data and\/or flow cytometry, and elevated lactate dehydrogenase (LDH). Limitations included missing data for LDH, imaging, peripheral blood TCR data, or flow cytometry assessed at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Staging and baseline laboratory assessments with imaging, peripheral blood flow cytometry, TCR data, and LDH in patients who have newly diagnosed MF may identify those who are at risk for progression to advanced stage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34579","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T01:34:25Z","timestamp":1671154465000},"page":"541-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Staging lymph nodes and blood at diagnosis in mycosis fungoides identifies patients at increased risk of progression to advanced stage: A retrospective cohort study"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-3662","authenticated-orcid":false,"given":"Pamela B.","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Hematology Winship Cancer Institute  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley A.","family":"McCook\u2010Veal","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics and Bioinformatics Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-9325","authenticated-orcid":false,"given":"Jeffrey M.","family":"Switchenko","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics and Bioinformatics Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darina M.","family":"Paulino","sequence":"additional","affiliation":[{"name":"Department of Hematology Winship Cancer Institute  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Niyogusaba","sequence":"additional","affiliation":[{"name":"Department of Hematology Winship Cancer Institute  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelin M.","family":"Baird","sequence":"additional","affiliation":[{"name":"Department of Hematology Winship Cancer Institute  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Tarabadkar","sequence":"additional","affiliation":[{"name":"Department of Hematology Winship Cancer Institute  Atlanta Georgia USA"},{"name":"Department of Dermatology Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Lechowicz","sequence":"additional","affiliation":[{"name":"Department of Hematology Winship Cancer Institute  Atlanta Georgia 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