{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:14:58Z","timestamp":1774520098418,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to estimate the cumulative risks of all cancers in women from 50 to 75\u00a0years of age with a <jats:italic>BRCA1 or BRCA2<\/jats:italic> pathogenic variant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were women with <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> pathogenic variants from 85 centers in 16 countries. Women were eligible if they had no cancer before the age of 50\u00a0years. Participants completed a baseline questionnaire and follow\u2010up questionnaires every 2 years. Women were followed from age 50 until a diagnosis of cancer, death, age 75, or last follow\u2010up. The risk of all cancers combined from age 50 to 75 was estimated using the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 2211 women included (1470 <jats:italic>BRCA1<\/jats:italic> and 742 <jats:italic>BRCA2<\/jats:italic>). There were 379 cancers diagnosed in the cohort between 50 and 75\u00a0years. The actuarial risk of any cancer from age 50 to 75 was 49% for <jats:italic>BRCA1<\/jats:italic> and 43% for <jats:italic>BRCA2<\/jats:italic>. Breast (<jats:italic>n<\/jats:italic>\u00a0=\u00a0186) and ovarian (<jats:italic>n<\/jats:italic>\u00a0=\u00a045) were the most frequent cancers observed. For women who had both risk\u2010reducing mastectomy and bilateral salpingo\u2010oophorectomy before age 50, the risk of developing any cancer between age 50 and 75 was 9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with a <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> pathogenic variant have a high risk of cancer between the ages of 50 and 75\u00a0years and should be counselled appropriately.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34615","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T09:34:10Z","timestamp":1672047250000},"page":"901-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The risks of cancer in older women with <i>BRCA<\/i> pathogenic variants: How far have we come?"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-2169","authenticated-orcid":false,"given":"Kelly A.","family":"Metcalfe","sequence":"first","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto Ontario Canada"},{"name":"Lawrence S. 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