{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:36:27Z","timestamp":1790660187797,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A lower baseline bone marrow blast percentage (bBMB%) is associated with better outcomes in patients with B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) receiving blinatumomab. The objective of this analysis was to investigate the association between bBMB% and treatment outcomes in relapsed\/refractory (R\/R) B\u2010ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from five trials of blinatumomab for R\/R B\u2010ALL were pooled for analyses. Patients were placed in one of three groups: group 1, \u226550% bBMBs; group 2, \u226525% to &lt;50% bBMBs; group 3, \u22655% to &lt;25% bBMBs. Response and survival outcomes were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 683 patients (166 pediatric, 517 adult) were analyzed. Collectively, patients in groups 2 and 3 had significantly higher odds of achieving a complete remission (CR) (odds ratio [OR], 3.50 [95% confidence interval (CI), 2.23\u20135.48] and 3.93 [95% CI, 2.50\u20136.18], respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and minimal\/measurable residual disease response (OR, 2.61 and 3.37, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) when compared with group 1 (reference). Groups 2 and 3 had a 37% and 46% reduction in the risk of death (hazard ratio [HR], 0.63 and 0.54, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and a 41% and 43% reduction in the risk of an event (relapse or death) (HR, 0.59 and 0.57, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) compared with group 1. No significant differences in response or survival outcomes were observed between groups 2 and 3. Seven of nine patients whose bBMB% was lowered to &lt;50% with dexamethasone achieved CR with blinatumomab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Any bBMB% &lt;50% was associated with improved efficacy following blinatumomab treatment for R\/R B\u2010ALL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34667","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:50:15Z","timestamp":1677286215000},"page":"1384-1393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Low leukemia burden improves blinatumomab efficacy in patients with relapsed\/refractory B\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"129","author":[{"given":"Manon","family":"Queudeville","sequence":"first","affiliation":[{"name":"Department of General Pediatrics, Hematology and Oncology Children's University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Stein","sequence":"additional","affiliation":[{"name":"Gehr Family Center for Leukemia Research City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology IRCCS Ospedale Pediatrico Bambino Ges\u00f9 Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ebinger","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Hematology and Oncology Children's University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Handgretinger","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Hematology and Oncology Children's University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"G\u00f6kbuget","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital Goethe University  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Gore","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology\/Oncology\/Bone Marrow Transplant\u2010Cellular Therapeutics University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-1467","authenticated-orcid":false,"given":"Yi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Oncology TA Amgen Inc.  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