{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:07:18Z","timestamp":1792494438706,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180899"],"award-info":[{"award-number":["U10CA180899"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Orbital rhabdomyosarcoma (ORMS) commonly presents as low\u2010risk disease (stage 1, group I\u2013III, embryonal RMS) with excellent outcome. Long\u2010term follow\u2010up of patients with low\u2010risk ORMS and outcomes of less common subgroups of ORMS treated on recent Children's Oncology Group (COG) trials have not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with ORMS enrolled on COG trials from 1997 to 2013 were identified. Demographic information and disease characteristics were collected. Outcomes were determined for the following subgroups: 1) low\u2010risk ORMS, 2) resected (group I\/II) low\u2010risk ORMS, 3) non\u2013low\u2010risk ORMS, and 4) recurrent ORMS. Event\u2010free survival (EFS) and overall survival (OS) were estimated using the Kaplan\u2013Meier method.<\/jats:p><jats:p>ResultsThe authors identified 218 patients with ORMS. Most tumors were embryonal\/botryoid (<jats:italic>n<\/jats:italic>\u00a0=\u00a0169; 77.5%), &lt;5\u00a0cm (<jats:italic>n<\/jats:italic>\u00a0=\u00a0213; 97.7%), group III (<jats:italic>n<\/jats:italic>\u00a0=\u00a0170; 78.0%), and without lymph node involvement (N0; <jats:italic>n<\/jats:italic>\u00a0=\u00a0215; 98.6%). For 192 patients with low\u2010risk ORMS, the 10\u2010year EFS and OS rates were 85.5% (95% confidence interval [CI], 77.0%\u201394.0%) and 95.6% (95% CI, 90.8%\u2013100.0%), respectively. Those with group I\/II low\u2010risk ORMS (<jats:italic>n<\/jats:italic> = 5 in group I; <jats:italic>n<\/jats:italic> = 39 in group IIA) had 10\u2010year EFS and OS rates of 88.0% (95% CI, 72.6%\u2013100.0%) and 97.6% (95% CI, 90.0%\u2013100.0%), respectively. Twenty\u2010six patients with non\u2013low\u2010risk ORMS had 5\u2010year EFS and OS rates of 88.5% (95% CI, 75.6%\u2013100.0%) and 95.8% (95% CI, 87.7%\u2013100.0%), respectively. For patients with recurrent ORMS, the 10\u2010year OS rate from the time of recurrence was 69.4% (95% CI, 50.0%\u201388.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with ORMS had favorable long\u2010term survival outcomes on COG studies from 1997 to 2013, including those who had both low\u2010risk and non\u2013low\u2010risk disease. A significant proportion of patients with recurrent ORMS may achieve long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34723","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T13:19:06Z","timestamp":1677676746000},"page":"1735-1743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Survival of patients with orbital and eyelid rhabdomyosarcoma treated on Children's Oncology Group studies from 1997 to 2013: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1068-7857","authenticated-orcid":false,"given":"Jonathan","family":"Metts","sequence":"first","affiliation":[{"name":"Cancer and Blood Disorders Institute Johns Hopkins All Children's Hospital  St Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health and Health Professions and College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengya","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health and Health Professions and College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Ermoian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7581-4605","authenticated-orcid":false,"given":"Julie A.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's Hospital Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Department of Pathology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4839-4937","authenticated-orcid":false,"given":"Roshni","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Venkatramani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Walterhouse","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ann &amp; Robert H. 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