{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:41:06Z","timestamp":1788810066689,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Contemporary risk\u2010directed treatment has improved the outcome of patients with acute lymphoblastic leukemia (ALL) and TCF3::PBX1<\/jats:italic> fusion. In this study, the authors seek to identify prognostic factors that can be used to further improve outcome.<\/jats:p><\/jats:sec>Methods<\/jats:title>The authors studied 384 patients with this genotype treated on Chinese Children's Cancer Group ALL\u20102015 protocol between January 1, 2015 and December 31, 2019. All patients provisionally received intensified chemotherapy in the intermediate\u2010risk arm without prophylactic cranial irradiation; those with high minimal residual disease (MRD) \u22651% at day 46 (end) of remission induction were candidates for hematopoietic cell transplantation.<\/jats:p><\/jats:sec>Results<\/jats:title>The overall 5\u2010year event\u2010free survival was 84.4% (95% confidence interval [CI], 80.6\u201388.3) and 5\u2010year overall survival 88.9% (95% CI, 85.5\u201392.4). Independent factors associated with lower 5\u2010year event\u2010free survival were male sex (80.4%, [95% CI, 74.8\u201386.4] vs. 88.9%, [95% CI, 84.1\u201393.9] in female, p<\/jats:italic>\u00a0=\u00a0.03) and positive day 46 MRD (\u22650.01%) (62.1%, [95% CI, 44.2\u201387.4] vs. 87.1%, [95% CI, 83.4\u201390.9] in patients with negative MRD, p<\/jats:italic>\u00a0<\u00a0.001). The presence of testicular leukemia at diagnosis (n<\/jats:italic>\u00a0=\u00a010) was associated with particularly dismal 5\u2010year event\u2010free survival (33.3% [95% CI, 11.6\u201396.1] vs. 83.0% [95% CI, 77.5\u201388.9] in the other 192 male patients, p<\/jats:italic>\u00a0<\u00a0.001) and was an independent risk factor (hazard ratio [HR], 5.7; [95% CI, 2.2\u201314.5], p<\/jats:italic>\u00a0<\u00a0.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These data suggest that the presence of positive MRD after intensive remission induction and testicular leukemia at diagnosis are indicators for new molecular therapeutics or immunotherapy in patients with TCF3::PBX1<\/jats:italic> ALL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34741","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T13:14:29Z","timestamp":1679404469000},"page":"1691-1703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1<\/i> in CCCG\u2010ALL\u20102015: A multicenter study"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6232-8579","authenticated-orcid":false,"given":"Honghong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital of Fudan University National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital of Fudan University National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University National Health Committee Key Laboratory of Pediatric Hematology & Oncology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Chongqing Medical University Affiliated Children's Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West China Second University Hospital Sichuan University Key Laboratory of Birth Defects and Related Disease of Women and Children Ministry of Education Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changda","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Jiangxi Provincial Children's Hospital Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runming","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Union Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology KunMing Children's Hospital Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital Affiliated to Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Xi'an Northwest Women's and Children's Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Anhui Medical University Second Affiliated Hospital Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex W. K.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hong Kong Children's Hospital The Chinese University of Hong Kong Hong Kong Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital of Fudan University National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoxiang","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital of Fudan University National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010kong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hong Kong Children's Hospital The Chinese University of Hong Kong Hong Kong Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee USA"},{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital Memphis Tennessee USA"},{"name":"Department of Pharmaceutical Sciences St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University National Health Committee Key Laboratory of Pediatric Hematology & Oncology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University National Health Committee Key Laboratory of Pediatric Hematology & Oncology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0303-5658","authenticated-orcid":false,"given":"Ching\u2010Hon","family":"Pui","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee USA"},{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital Memphis Tennessee USA"},{"name":"Department of Pharmaceutical Sciences St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-0302","authenticated-orcid":false,"given":"Xiaowen","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital of Fudan University National Children's Medical Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.59.1636"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1400972"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.265"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.64.6364"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v63.3.721.721"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12400"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.15.2001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.6826"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v87.4.1211.bloodjournal8741211"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v76.1.117.bloodjournal761117"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1994.12.12.2601"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.42"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140\u20106736(91)90733\u20106"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11239"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s115257"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27346"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2021.100758"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643\u20103230.bcd\u201020\u20100229"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010438"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(21)00328\u20104"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403135"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403340"},{"key":"e_1_2_9_24_1","first-page":"2054","article-title":"Expression of identical E2A\/PBX1 fusion transcripts occurs in both pre\u2010B and early pre\u2010B immunological sub\u2010types of childhood acute lymphoblastic leukemia","volume":"7","author":"Izraeli S","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/9781118032985","volume-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch JD","year":"2002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555\u2010019\u201009834\u20100"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012727"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.01692"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.10.016"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01214"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001307"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26324"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.34741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:57:03Z","timestamp":1760295423000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.34741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,21]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/cncr.34741"],"URL":"https:\/\/doi.org\/10.1002\/cncr.34741","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,21]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}