{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:36:12Z","timestamp":1792067772728,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170212"],"award-info":[{"award-number":["82170212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974002"],"award-info":[{"award-number":["81974002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Minimal residual disease (MRD) is an important prognostic factor for survival in adults with acute leukemia. The role of pretransplantation MRD status in myelodysplastic syndrome with excess blasts (MDS\u2010EB) is unknown. This study retrospectively analyzed the relationship between pretransplantation MRD status and long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with MDS\u2010EB who underwent allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) from March 5, 2005, to November 8, 2020, were included. The relationship between pretransplantation MRD status and long\u2010term survival was analyzed using univariate and multivariate logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 220 patients with MDS\u2010EB who underwent allo\u2010HSCT, 198 were eligible for inclusion in this multicenter, retrospective cohort study. Complete remission was attained in 121 (61.1%) patients, and 103 patients underwent detection of MRD pretransplantation, with 67 patients being MRD\u2010positive and 36 patients being MRD\u2010negative. The median follow\u2010up time was 16\u00a0months, the median age was 41\u00a0years (6\u201365\u00a0years), and 58% of the patients were men. The 3\u2010year disease\u2010free survival (DFS) and overall survival (OS) probabilities for all patients were 70.1% and 72.9%, respectively. For patients in complete remission, the 3\u2010year DFS and OS probabilities were 72.2% and 74.8%, respectively. Further analysis found that the 3\u2010year DFS rates of MRD\u2010negative and MRD\u2010positive patients were 85.6% and 66.5% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.045), respectively, whereas the 3\u2010year OS rates were 91.3% and 66.4% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035), respectively. Univariate and multivariate analyses showed that poor pretransplantation MRD clearance was an independent prognostic risk factor for DFS and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Poor pretransplantation MRD clearance is an independent prognostic risk factor for long\u2010term survival after allo\u2010HSCT for patients with MDS\u2010EB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain language summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Poor minimal residual disease clearance pretransplanation is an independent prognostic risk factor for long\u2010term survival after allogeneic hematopoietic stem cell transplantation for patients with myelodysplastic syndrome with excess blasts.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34762","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T09:22:02Z","timestamp":1679563322000},"page":"2013-2022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Poor pretransplantation minimal residual disease clearance as an independent prognostic risk factor for survival in myelodysplastic syndrome with excess blasts: A multicenter, retrospective cohort study"],"prefix":"10.1002","volume":"129","author":[{"given":"Ying\u2010Ying","family":"Ma","sequence":"first","affiliation":[{"name":"Medical Center of Hematology Xinqiao Hospital State Key Laboratory of Trauma, Burn and Combined Injury Army Medical University  Shapingba District, Chongqing 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of Trauma, Burn and Combined Injury Army Medical University  Shapingba District, Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Yan","family":"Kong","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology Xinqiao Hospital State Key Laboratory of Trauma, Burn and Combined Injury Army Medical University  Shapingba District, Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wen","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology Xinqiao Hospital State Key Laboratory of Trauma, Burn and Combined Injury Army Medical University  Shapingba District, Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Hematology The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army  Lanzhou Gansu 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