{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:47:41Z","timestamp":1778917661280,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate if peritoneal mesothelioma (PM) patients with germline mutations (GM) have distinct surgical characteristics when compared to those without GM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PM patients were selected from an ongoing prospective study that conducts germline testing of 82 susceptibility genes. Germline status was correlated with surgical data obtained from a prospectively collected database using univariate, multivariate, and receiver operating characteristic (ROC) analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 88 PM patients enrolled between 2009 and 2019, 18\u00a0GMs (20.5%) were identified in BRCA1\u2010associated protein 1 (<jats:italic>BAP1<\/jats:italic>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a011, 12.5% of all patients), <jats:italic>SDHA<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and <jats:italic>WT1<\/jats:italic>, <jats:italic>CDKN2A<\/jats:italic>, <jats:italic>CHEK2<\/jats:italic>, <jats:italic>ATM<\/jats:italic>, and <jats:italic>BRCA2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01 patient each). Surgical procedures were performed in 71 patients, the most common of which were cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a061). Patients with GM presented with a higher prevalence of other prior cancers (61.1% vs. 31.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and lower platelet count (251 [160\u2013413] vs. 367 [196\u2013780] K\/\u00b5L, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005) compared to those without GM (<jats:italic>n<\/jats:italic>\u00a0=\u00a070). Survival outcomes did not differ significantly between the groups. Patients with <jats:italic>BAP1<\/jats:italic> GMs were more likely to develop bicavitary disease and to present with lower platelet count and mitotic count score, and higher peritoneal cancer index (PCI, all <jats:italic>p<\/jats:italic>\u00a0\u2264\u00a0.04) compared with those without GM. On ROC analysis, the combination of PCI, platelet count and mitotic score yielded an area under the curve of 0.96 (95% CI, 0.91\u20131.0) for <jats:italic>BAP1<\/jats:italic> GM detection among operated PM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher intraoperative tumor burden and lower platelet count and mitotic score are suggestive of <jats:italic>BAP1<\/jats:italic> GMs in surgical PM patients and should prompt germline testing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34763","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T08:20:01Z","timestamp":1681287601000},"page":"2152-2160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical phenotype of patients with peritoneal mesothelioma and a germline mutation"],"prefix":"10.1002","volume":"129","author":[{"given":"Yaniv","family":"Berger","sequence":"first","affiliation":[{"name":"Department of Surgery Sheba Medical Center, Tel Hashomer Affiliated to the Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghana","family":"Gadiraju","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology Department of Medicine University of Chicago Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Section of Surgical Oncology Department of Surgery University of Chicago Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Gilliam","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology Department of Medicine University of Chicago Medical Center  Chicago 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