{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:50:58Z","timestamp":1789854658135,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study compares a comprehensive range of psychosocial outcomes of adult childhood cancer survivors (CCS) to general population\u2010based references and identifies sociodemographic and medical risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)\u2010LATER cohort (diagnosed 1963\u20132001) part 2 (attained age \u226518 years, diagnosed &lt;18 years, \u22655\u00a0years since diagnosis) completed the Rosenberg Self\u2010Esteem Scale, Hospital Anxiety and Depression Scale, Distress Thermometer, Self\u2010Rating Scale for Post\u2010Traumatic Stress Disorder, and the Short Form\u201036 (Health Related Quality of Life). CCS\u2019 scores were compared with references using analysis of variances and logistic regression analysis, controlling for age and sex (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Risk factors for worse psychosocial outcomes were assessed with regression analyses (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CCS, <jats:italic>N<\/jats:italic>\u00a0=\u00a01797, mean age 35.4\u00a0years, 49.0% female, all \u226515\u00a0years since diagnosis, participated. Three percent reported posttraumatic stress disorder because of childhood cancer and 36.6% experienced clinical distress. CCS did not differ from references on self\u2010esteem and anxiety but were less depressed (d\u00a0=\u00a0\u2212.25), and scored poorer on all health\u2010related quality of life scales, except for bodily pain (.01\u00a0\u2264\u00a0d\u00a0\u00a0\u2265\u00a0\u00a0\u2212.36). Female sex, lower educational attainment, not being in a relationship, and being unemployed were negatively associated with almost all psychosocial outcomes. Except for a central nervous system tumor diagnosis, few medical characteristics were associated with psychosocial outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CCS appear resilient regarding mental health but have slightly poorer health\u2010related quality of life than references. Sociodemographic characteristics and central nervous system tumors were related to most psychosocial outcomes, but no clear pattern was observed for other medical factors. Future studies should address additional factors in explaining CCS\u2019 psychosocial functioning, such as coping, social support, and physical late effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34795","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T03:13:35Z","timestamp":1681442015000},"page":"2553-2567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Psychosocial outcomes in long\u2010term Dutch adult survivors of childhood cancer: The DCCSS\u2010LATER 2 psycho\u2010oncology study"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-1802","authenticated-orcid":false,"given":"Anne","family":"Maas","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen","family":"Maurice\u2010Stam","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontien C. 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E.","family":"Tissing","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Beatrix Children's Hospital\/University of Groningen\/University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline J.","family":"Loonen","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J. H.","family":"van der Pal","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrica C. 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