{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:54:18Z","timestamp":1788216858813,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity (body mass index [BMI] \u226530\u00a0kg\/m<jats:sup>2<\/jats:sup>) is an important epidemiological risk factor for developing acute myeloid leukemia (AML). Therefore, the authors studied the association of obesity with clinical and genetic phenotype and its impact on outcome in adults with AML.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors analyzed BMI in 1088 adults who were receiving intensive remission induction and consolidation therapy in two prospective, randomized therapeutic clinical trials of the Eastern Cooperative Oncology Group\u2010American College of Radiology Imaging Network: E1900 (ClinicalTrials.gov identifier NCT00049517; patients younger than 60\u00a0years) and E3999 (ClinicalTrials.gov identifier NCT00046930; patients aged 60\u00a0years or older).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obesity was prevalent at diagnosis (33%) and, compared with nonobesity, was associated with intermediate\u2010risk cytogenetics group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.008), poorer performance status (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01), and a trend toward older age (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.06). Obesity was not associated with somatic mutations among a selected 18\u2010gene panel that was tested in a subset of younger patients. Obesity was not associated with clinical outcome (including complete remission, early death, or overall survival), and the authors did not identify any patient subgroup that had inferior outcomes based on BMI. Obese patients were significantly more likely to receive &lt;90% of the intended daunorubicin dose despite protocol specification, particularly in the E1900 high\u2010dose (90\u00a0mg\/m<jats:sup>2<\/jats:sup>) daunorubicin arm (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002); however, this did not correlate with inferior overall survival on multivariate analysis (hazard ratio, 1.39; 95% confidence interval, 0.90\u20132.13; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obesity is associated with unique clinical and disease\u2010related phenotypic features in AML and may influence physician treatment decisions regarding daunorubicin dosing. However, the current study demonstrates that obesity is not a factor in survival, and strict adherence to body surface area\u2010based dosing is not necessary because dose adjustments do not affect outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34807","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T02:16:19Z","timestamp":1682475379000},"page":"2479-2490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG\u2010ACRIN analysis"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-1708","authenticated-orcid":false,"given":"James M.","family":"Foran","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology and Mayo Clinic Cancer Center Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Eastern Cooperative Oncology Group\u2010American College of Radiology Imaging Network (ECOG\u2010ACRIN) Biostatistics Center Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-0281","authenticated-orcid":false,"given":"Catherine","family":"Lai","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo F.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Blood &amp; Marrow Transplantation H. Lee Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry D.","family":"Cripe","sequence":"additional","affiliation":[{"name":"Indiana University Melvin and Bren Simon Cancer Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhett P.","family":"Ketterling","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology and Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Racevskis","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina M.","family":"Luger","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Paietta","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillard M.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\u2010Oncology Case Comprehensive Cancer Center University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cytogenetics Laboratory Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Hematopathology Division Department of Pathology James P. Wilmot Cancer Institute University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross L.","family":"Levine","sequence":"additional","affiliation":[{"name":"Cytogenetics Laboratory Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Litzow","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology and Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Tallman","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Robert H. 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