{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:48:17Z","timestamp":1785610097228,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data exist on the clinical behavior of pediatric non\u2010rhabdomyosarcoma soft tissue sarcomas (NRSTS) with distant metastases at onset, and a clear standard of care has not yet been defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study reports on pediatric adult\u2010type metastatic NRSTS enrolled in two concurrent prospective European studies, i.e., the randomized BERNIE study and the single\u2010arm MTS 2008 study developed by the European paediatric Soft tissue sarcoma Study Group. Treatment programs were originally designed for patients with metastatic rhabdomyosarcoma, i.e., nine courses of multidrug chemotherapy (with or without bevacizumab in the BERNIE study), followed by 12 cycles of maintenance therapy, whereas radiotherapy and\/or surgery (on primary tumor and\/or metastases) were delayed until after seven courses of chemotherapy had been administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 61 patients &lt;21\u00a0years old treated from July 2008 to December 2016. The lung was the site of metastases in 75% of the cases. All patients received multi\u2010agent chemotherapy, 44% had local therapy to primary tumor, and 18% had treatment of metastases. Median time to progression\/relapse was 6\u00a0months. A high rate of tumor progression was observed during the initial part of the chemotherapy program. With a median follow\u2010up of 41.5\u00a0months (range, 2\u2013111\u00a0months), 3\u2010year event\u2010free survival and overall survival were 15.4% (95% confidence interval [CI], 7.6\u201325.7) and 34.9% (95% CI, 22.7\u201347.5), respectively. There were no statistically significant differences in outcome depending on the type of treatment administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study confirmed the overall poor outcome for patients with metastatic NRSTS, whose treatment remains a challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Pediatric non\u2010rhabdomyosarcoma soft tissue sarcomas form a heterogeneous group of rare tumors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Although recent international studies have defined the standard of care for patients with localized disease, limited data are available on the clinical behavior of patients with distant metastases.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This study on 61 metastatic cases treated on two prospective European protocols confirms that the chances of survival of such patients are often dismal and a standard treatment is still lacking.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34814","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T12:08:21Z","timestamp":1682078901000},"page":"2542-2552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Metastatic adult\u2010type non\u2010rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4724-0517","authenticated-orcid":false,"given":"Andrea","family":"Ferrari","sequence":"first","affiliation":[{"name":"Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale Tumori  Milano 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