{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:21:43Z","timestamp":1783408903407,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003156","name":"Musella Foundation For Brain Tumor Research and Information","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["75D30119C06056"],"award-info":[{"award-number":["75D30119C06056"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["Amendment\/ModificationNo"],"award-info":[{"award-number":["Amendment\/ModificationNo"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["00002\u201003"],"award-info":[{"award-number":["00002\u201003"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001794","name":"Pediatric Brain Tumor Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012634","name":"Novocure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006064","name":"Sontag Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019451","name":"Uncle Kory Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001512","name":"National Brain Tumor Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary brain tumors (BTs) are rare, but cause morbidity and mortality disproportionately to their incidence. Prevalence estimates population\u2010level cancer burdens at a specified time. This study estimates the prevalence of malignant and non\u2010malignant BTs in comparison to other cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Incidence data were obtained from the Central Brain Tumor Registry of the United States (2000\u20132019, varying), a combined data set including the Center for Disease Control and Prevention's National Program of Cancer Registries and National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program. Incidence of non\u2010BT cancers were obtained from the United States Cancer Statistics (2001\u20132019). Incidence and survival estimates for all cancers were obtained from SEER (1975\u20132018). Complete prevalence as of December 31, 2019, was estimated using <jats:italic>prevEst<\/jats:italic>. Estimates were generated overall for non\u2010BT cancers, by BT histopathology, age groups at prevalence (0\u201314, 15\u201339, 40\u201364, 65+ years), and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We estimated 1,323,121 individuals with a diagnosis of BTs at the date of prevalence. The majority of BT cases had non\u2010malignant tumors (85.3%). Among all cancers, BTs were the most prevalent cancer type among those ages 15 to 39\u00a0years, second among those ages 0 to 14\u00a0years, and in the top five among those ages 40 to 64\u00a0years. The plurality of prevalent cases (43.5%) occurred among those ages 65+ years. Overall, females had a higher prevalence of BTs than males, with an overall female:male prevalence ratio of 1.68.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BTs contribute significantly to the cancer burden in the United States, particularly among those younger than age 65\u00a0years. Understanding complete prevalence is crucial for monitoring cancer burden to inform clinical research and public policy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34837","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T10:59:57Z","timestamp":1684407597000},"page":"2514-2521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Complete prevalence of primary malignant and nonmalignant brain tumors in comparison to other cancers in the United States"],"prefix":"10.1002","volume":"129","author":[{"given":"Corey","family":"Neff","sequence":"first","affiliation":[{"name":"Central Brain Tumor Registry of the United States  Hinsdale Illinois USA"},{"name":"Department of Neurosurgery Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-0609","authenticated-orcid":false,"given":"Mackenzie","family":"Price","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States  Hinsdale Illinois USA"},{"name":"Department of Neurosurgery Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Cioffi","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States  Hinsdale Illinois USA"},{"name":"Trans\u2010Divisional Research Program (TDRP) Division of Cancer Epidemiology and Genetics (DCEG) National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Kruchko","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States  Hinsdale Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin A.","family":"Waite","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States  Hinsdale Illinois USA"},{"name":"Trans\u2010Divisional Research Program (TDRP) Division of Cancer Epidemiology and Genetics (DCEG) National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill S.","family":"Barnholtz\u2010Sloan","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States  Hinsdale Illinois USA"},{"name":"Trans\u2010Divisional Research Program (TDRP) Division of Cancer Epidemiology and Genetics (DCEG) National Cancer Institute  Bethesda Maryland USA"},{"name":"Center for Biomedical Informatics &amp; Information Technology (CBIIT) National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-7558","authenticated-orcid":false,"given":"Quinn T.","family":"Ostrom","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States  Hinsdale Illinois USA"},{"name":"Department of Neurosurgery Duke University School of Medicine  Durham North Carolina USA"},{"name":"The Preston Robert Tisch Brain Tumor Center Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Cancer Institute Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab200"},{"key":"e_1_2_9_3_1","unstructured":"Cancer Registries Amendment Act 102nd Cong. \u00a7 515(1992). Accessed July 21 2020.https:\/\/www.govinfo.gov\/content\/pkg\/STATUTE\u2010106\/pdf\/STATUTE\u2010106\u2010Pg3372.pdf"},{"key":"e_1_2_9_4_1","unstructured":"Benign Brain Tumor Cancer Registries Amendment Act 107th Cong. \u00a7 260(2002). Accessed July 21 2020.http:\/\/www.gpo.gov\/fdsys\/pkg\/PLAW\u2010107publ260\/pdf\/PLAW\u2010107publ260.pdf"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1304"},{"key":"e_1_2_9_6_1","unstructured":"De AngelisR.MIAMOD\/PIAMOD. Istituto Superiore di Sanit\u00e0. Accessed November 4 2022.http:\/\/www.eurocare.it\/MiamodPiamod\/tabid\/60\/Default.aspx#software"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3010"},{"key":"e_1_2_9_8_1","unstructured":"National Cancer Institute Division of Cancer Control & Population Sciences Surveillance Research Program.Complete prevalence (ComPrev) software National Cancer Institute. Accessed November 4 2022.https:\/\/surveillance.cancer.gov\/comprev\/"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now252"},{"key":"e_1_2_9_10_1","volume-title":"International Classification of Diseases for Oncology","author":"Fritz APC","year":"2000"},{"key":"e_1_2_9_11_1","unstructured":"Central Brain Tumor Registry of the United States SEER*Stat Database. CDC National Program of Cancer Registries and NCI Surveillance Epidemiology and End Results Incidence Data 2021 submission (2000\u20132019).2022."},{"key":"e_1_2_9_12_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. SEER*Stat Database: incidence \u2010 SEER Research Plus Data 8 Registries Nov 2021 Sub (1975\u20102019) \u2010 Linked To County Attributes \u2010 Total U.S. 1969\u20102020 Counties National Cancer Institute DCCPS Surveillance Research Program released April 2022 based on the November 2021 submission.2022."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz202"},{"key":"e_1_2_9_14_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. SEER*Stat software version 8.4.0. National Cancer Institute DCCPS Surveillance Research Program. Accessed May 27 2022.www.seer.cancer.gov\/seerstat"},{"key":"e_1_2_9_15_1","unstructured":"R Core Team.A language and environment for statistical computing. R Foundation for Statistical Computing. Accessed April 20 2021.http:\/\/www.R\u2010project.org\/"},{"key":"e_1_2_9_16_1","unstructured":"NeffC ZhangAS PriceM Barnholtz\u2010SloanJS OstromQT.prevEst(version 2.0);2022.https:\/\/github.com\/ostrom\u2010lab\/prevEst"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npaa039"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.185"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3016"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010010\u20100386\u20103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkab035"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.7.JNS131644"},{"issue":"1","key":"e_1_2_9_23_1","first-page":"50","article-title":"Laser interstitial thermal therapy","volume":"117","author":"Patel B","year":"2020","journal-title":"Mo Med"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.817296"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.18718"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:31:24Z","timestamp":1760301084000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.34837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,18]]},"references-count":24,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2023,8,15]]}},"alternative-id":["10.1002\/cncr.34837"],"URL":"https:\/\/doi.org\/10.1002\/cncr.34837","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,18]]},"assertion":[{"value":"2022-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}