{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:55:00Z","timestamp":1784829300011,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The treatment of patients with myelofibrosis (MF) has evolved in the past decade, as reflected in an increased use of various therapeutic agents that could potentially impact patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In this retrospective study, the authors evaluated the pattern of therapy and its possible impact on the survival of patients with MF at their institution. Patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0802) with newly diagnosed, chronic, overt MF (MF fibrosis grade \u22652, &lt;10% blasts) seen at their cancer center between 2000 and 2020 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall, 492 of the included patients (61%) initiated MF\u2010directed therapy during follow\u2010up. The most frequent initial therapy was the JAK inhibitor ruxolitinib (44% of treated patients), investigational agents excluding JAK inhibitors (21%), immunomodulatory agents (18%), other investigational JAK inhibitors (10%), and others (7%). Overall survival was superior for patients who received initial ruxolitinib therapy, with a median survival of 72\u00a0months versus approximately 50\u00a0months for the remaining approaches, excluding the last group.\u00a0Thirty\u2010two percent of patients required subsequent therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a0159). The longest survival since the start of second\u2010line therapy was observed in patients who initiated salvage ruxolitinib (median, 35\u00a0months; 95% CI, 25\u201345 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study demonstrated improved outcomes of patients with MF who received treatment with the JAK inhibitor ruxolitinib.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34851","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T10:40:08Z","timestamp":1685184008000},"page":"2828-2835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of therapy in the outcome of patients with myelofibrosis"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6624-4196","authenticated-orcid":false,"given":"Lucia","family":"Masarova","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of 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