{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:10:42Z","timestamp":1790111442756,"version":"4.0.1"},"reference-count":100,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The published literature on hematological, clinical, flowcytometric\u2010immunophenotyping, and minimal residual disease outcomes of the prognostically important genetic subtypes of acute lymphoblastic leukemia (ALL) is scarce from low\u2010income countries. For newer classifications such as\n BCR::ABL1<\/jats:italic>\n \u2010like ALLs, the scarcity of patient\u2010level data is even more pronounced.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The authors performed comprehensive detection of recurrent gene fusions and\n BCR::ABL1<\/jats:italic>\n \u2010like ALL cases followed by immunophenotypic profiling and obtained clinical outcome parameters for a large cohort (\n n<\/jats:italic>\n \u00a0=\u00a01021) of patients from India. This cohort included a significant number of patients with\n BCR::ABL1<\/jats:italic>\n \u2010like ALL subtype and other genetic subtypes of ALL.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with\n BCR::ABL1<\/jats:italic>\n \u2010positive and\n BCR::ABL1<\/jats:italic>\n \u2010like ALL were significantly older, had male preponderance, and expressed a higher white blood cell count than\n BCR::ABL1<\/jats:italic>\n \u2010negative cases (\n p<\/jats:italic>\n \u00a0<\u00a0.05). Logistic regression modeling of B\u2010lineage\u2010ALL (B\u2010ALL) subtypes revealed that cluster of differentiation (CD)36 is a strong statistically significant predictive marker of\n BCR::ABL1<\/jats:italic>\n \u2010like ALL (\n p<\/jats:italic>\n \u00a0<\u00a0.05). Furthermore, patients with\n BCR::ABL1<\/jats:italic>\n \u2010like ALLs show a significantly higher frequency of CD36 expression compared to\n BCR::ABL1<\/jats:italic>\n \u2010negative ALLs (\n p<\/jats:italic>\n \u00a0<\u00a0.05). In terms of clinical symptoms, lymphadenopathy is a strong statistically significant predictive marker in\n BCR::ABL1<\/jats:italic>\n \u2010like ALLs compared to\n BCR::ABL1<\/jats:italic>\n \u2010negative ALL cases (\n p<\/jats:italic>\n \u00a0<\u00a0.05). In terms of treatment outcomes, minimal residual disease (MRD) positivity in\n BCR::ABL1<\/jats:italic>\n \u2010positive ALL cases were statistically significant (\n p<\/jats:italic>\n \u00a0<\u00a0.05), and\n BCR::ABL1<\/jats:italic>\n \u2010like ALL cases had high MRD\u2010positivity as compared to\n BCR::ABL1<\/jats:italic>\n \u2010negative ALL cases but did not show statistical significance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The findings evince the use of novel therapies and personalized treatment regimens to improve the overall survival of the newer incorporated entities in B\u2010ALLs. This is the first report characterizing the hematological, clinical, flowcytometric\u2010immunophenotyping, and minimal residual disease outcomes of the prognostically significant subtypes of ALLs in patients from India.<\/jats:p>\n <\/jats:sec>\n \n Plain Language Summary<\/jats:title>\n \n \n \n \n Characterizing the hematological, clinical, flowcytometric\u2010immunophenotyping, and minimal residual disease outcomes of the prognostically significant subtypes (\n n<\/jats:italic>\n \u00a0=\u00a01021) of acute lymphoblastic leukemia (ALLs) in patients from India.\n <\/jats:p>\n <\/jats:list-item>\n \n We have made two independent logistic regression models of cluster of differentiation (CD) markers and clinical symptoms to differentiate prognostically significant subtypes of ALLs.<\/jats:p>\n <\/jats:list-item>\n \n \n Logistic regression analysis of CD markers revealed CD36 as a strong predictor in\n BCR::ABL1<\/jats:italic>\n \u2010like ALL cases compared to\n BCR::ABL1<\/jats:italic>\n \u2010negative ALL cases.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Logistic regression analysis of clinical symptoms revealed lymphadenopathy significantly predicts\n BCR::ABL1<\/jats:italic>\n \u2010like ALLs (\n p<\/jats:italic>\n \u00a0<\u00a0.05).\n <\/jats:p>\n <\/jats:list-item>\n \n \n In terms of treatment outcomes,\n BCR::ABL1<\/jats:italic>\n \u2010positive ALL had statistically significant minimal residual disease (MRD) (\n p<\/jats:italic>\n \u00a0<\u00a0.05), and\n BCR::ABL1<\/jats:italic>\n \u2010like ALL cases had high MRD\u2010positivity but did not show statistical significance as compared to\n BCR::ABL1<\/jats:italic>\n \u2010negative ALLs.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cncr.34957","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T13:50:58Z","timestamp":1690465858000},"page":"3390-3404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B\u2010lineage acute lymphoblastic leukemia: A report of 1021 patients from India"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-7585","authenticated-orcid":false,"given":"Dikshat Gopal","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Urology and Pathology The Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Hematology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Hematology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai I.","family":"Truica","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology The Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarki A.","family":"Abdulkadir","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology The Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmod","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Anatomy Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Updesh","family":"Singh Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Hematology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shano","family":"Naseem","sequence":"additional","affiliation":[{"name":"Department of Hematology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Rizwan","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine and Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Hematology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jogeshwar","family":"Binota","sequence":"additional","affiliation":[{"name":"Department of Hematology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology and Medical Oncology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Khadwal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Trehan","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Oncology Unit Department of Pediatrics Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001159\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.10.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899\u2010016\u20100326\u20101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.70.7836"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation\u20102014.1.174"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1403088"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/edbk_156628"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1999439"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.270645"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201003\u2010643544"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001620\u20102"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201007\u2010726588"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.69.0073"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.136366"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201012\u2010758979"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v122.21.826.826"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(08)70339\u20105"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.117424"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0808253"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.162925"},{"issue":"7","key":"e_1_2_9_22_1","first-page":"554","article-title":"Philadelphia chromosome\u2010like acute lymphoblastic leukemia: progress in a new cancer subtype","volume":"15","author":"Wells J","year":"2017","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062193"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010020\u20100308\u20103"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.09.001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.749361"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019\u20100194\u2010ra"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15251"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31848"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.207019"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.03.299"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201004\u2010841676"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v126.23.2610.2610"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201006\u2010743252"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201099\u2010115035"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25126"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288\u2010018\u20100997\u2010y"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.247973"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.galenos.2021.2021.0326"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20101482.147716"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u2010553x.2007.00954.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338260"},{"key":"e_1_2_9_43_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team"},{"key":"e_1_2_9_44_1","unstructured":"LongJA.jtools: Analysis and presentation of social scientific data. R package version 2.2.0.2022.https:\/\/cran.r\u2010project.org\/package=jtools"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701343255"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phoj.2018.11.052"},{"issue":"12","key":"e_1_2_9_47_1","first-page":"1065","article-title":"Role of mid\u2010induction peripheral blood minimal residual disease detection in pediatric B\u2010lineage acute lymphoblastic leukemia","volume":"53","author":"Bommannan K","year":"2016","journal-title":"Indian Pediatr"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21831"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201011\u2010253435"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201011\u2010394221"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12400"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2018.08.009"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2019.017"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1929964"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010021\u201000504\u20105"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-03856-y"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2020.2020255"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201007\u20102922"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201010\u2010051912"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.23"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.4103\/kleuhsj.kleuhsj_170_21"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34665"},{"key":"e_1_2_9_63_1","doi-asserted-by":"crossref","unstructured":"MMdosSantos ASdS HHdeMSantos LdaSilva Santos RJos\u00e9 MNascimento AJLTorres.Immunophenotypic characterization of acute leukemias in Bahia Brazil. Einstein (S\u00e3o Paulo).2023;21:eAO0117.","DOI":"10.31744\/einstein_journal\/2023AO0117"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.25259\/jhas_26_2021"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2021.03"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320\u20106012.ijrms20210882"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.30699\/ijp.2019.93974.1926"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3233\/cbm\u2010150482"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12716"},{"issue":"2","key":"e_1_2_9_70_1","first-page":"99","article-title":"Aberrant expression of CD markers in acute leukemia","volume":"9","author":"Chughtai O","year":"2013","journal-title":"Ann Pak Inst Med Sci"},{"issue":"28","key":"e_1_2_9_71_1","article-title":"Flowcytometric immunophenotypic profile of acute leukemia: Mansoura experience","volume":"2","author":"El\u2010Aziz DASSMA","year":"2012","journal-title":"Indian J Hematol Blood Transfus"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10385"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.21.5.a384\u2010c"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/135186"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1309\/ajcp8g5rmtwuemuu"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.4103\/kleuhsj.kleuhsj_170_21"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097678"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20451"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402504"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201004\u2010016709"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526616688753"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201005\u20101866"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201010\u2010183483"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1309\/ajcpan7bh5dnywzb"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2017.1333294"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0256801"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00726"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28929"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403001"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201001\u2010132837"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199808273390904"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27590"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(98)04058\u20106"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.56.0698"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.011346"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.207506"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13834"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010012\u20100247\u20107"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081847"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519782"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010023\u201002294\u2010y"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:18:39Z","timestamp":1760285919000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.34957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":100,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/cncr.34957"],"URL":"https:\/\/doi.org\/10.1002\/cncr.34957","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]},"assertion":[{"value":"2023-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}