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Treatments like Janus kinase inhibitor monotherapy (e.g., ruxolitinib) provide significant spleen and symptom relief but demonstrate limited ability to lead to a durable disease modification. There is an urgent unmet medical need for treatments with a novel mechanism of action that can modify the underlying pathophysiology and affect the disease course of myelofibrosis. This review highlights the role of B\u2010cell lymphoma (BCL) protein BCL\u2010extra large (BCL\u2010X<jats:sub>L<\/jats:sub>) in disease pathogenesis and the potential role that navitoclax, a BCL\u2010extra large\/BCL\u20102 inhibitor, may have in myelofibrosis treatment.<\/jats:p>","DOI":"10.1002\/cncr.34986","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T01:35:37Z","timestamp":1692408937000},"page":"3535-3545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["New era for myelofibrosis treatment with novel agents beyond Janus kinase\u2010inhibitor monotherapy: Focus on clinical development of BCL\u2010X<sub>L<\/sub>\/BCL\u20102 inhibition with navitoclax"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-6513","authenticated-orcid":false,"given":"Naveen","family":"Pemmaraju","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline S.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-7093","authenticated-orcid":false,"given":"Andrew","family":"Perkins","sequence":"additional","affiliation":[{"name":"Australian Centre for Blood Diseases Monash University, and the Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Harb","sequence":"additional","affiliation":[{"name":"AbbVie Inc.  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