{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T09:52:43Z","timestamp":1789293163487,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to compare two immunosuppressive strategies, based on the use of either rabbit antithymocyte globulin (ATG) or posttransplant cyclophosphamide (PTCY), as a prophylaxis of graft\u2010versus\u2010host disease (GVHD) for patients with acute lymphoblastic leukemia (ALL) in first complete remission who underwent hematopoietic cells transplantation from matched unrelated donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 117 and 779 adult patients who received PTCY and ATG, respectively, between the years 2015 and 2020 were included in this retrospective study. The median patient age was 40 and 43\u00a0years in the PTCY and ATG groups, respectively, and 37% and 35% of patients, respectively, had Philadelphia chromosome\u2010positive ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In univariate analysis, the cumulative incidence of acute and chronic GVHD did not differ significantly between the study groups. The cumulative incidence of relapse at 2\u00a0years was reduced in the PTCY group (18% vs. 25%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.046) without a significant impact on nonrelapse mortality (11% vs. 16% in the ATG group; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.29). The rates of leukemia\u2010free survival (LFS) and overall survival were 71% versus 59%, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01), and 82% versus 74%, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.08). In multivariate analysis, the receipt of ATG compared with PTCY was associated with a reduced risk of extensive chronic GVHD (hazard ratio, 0.54; 95% confidence interval, 0.3\u20130.98; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04) and an increased risk of low LFS (hazard ratio, 1.57; 95% confidence interval, 1.01\u20132.45; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The receipt of ATG compared with PTCY, despite the reduced risk of extensive chronic GVHD, is associated with inferior LFS in adults with ALL who undergo hematopoietic cell transplantation from 10\/10 human leukocyte antigen\u2010matched unrelated donors. These findings warrant verification in prospective trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35004","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T02:04:41Z","timestamp":1693620281000},"page":"3735-3745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Posttransplant cyclophosphamide versus antithymocyte globulin in patients with acute lymphoblastic leukemia treated with allogeneic hematopoietic cell transplantation from matched unrelated donors: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4827-4401","authenticated-orcid":false,"given":"Sebastian","family":"Giebel","sequence":"first","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cellular Therapy National Institute of Health and Medical Research Unit UMR\u2010S 938 Sorbonne University and St Anthony Scientific Research Center Public Assistance Hospital of Paris St Anthony Hospital  Paris France"},{"name":"European Society for Blood and Marrow Transplantation Paris Study Office\/CEREST\u2010TC  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urpu","family":"Salmenniemi","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation Unit Helsinki University Hospital Comprehensive Cancer Center  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Hematology National Institute of Health and Medical Research Unit U976 Public Assistance Hospital of Paris St Louis Hospital University of Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute Pavlov University  St Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Transplantation and Cellular Therapy Program Cancer Research Center of Marseille Paoli Calmettes Institute  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center Eppendorf University Hospital  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vydra","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Grassi","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital \u201cPapa Giovanni XXIII\u201d  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bonifazi","sequence":"additional","affiliation":[{"name":"Institute of Hematology \u201cL. e A. Ser\u00e0gnoli\u201d IRCCS University Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Czerw","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achilles","family":"Anagnostopoulos","sequence":"additional","affiliation":[{"name":"Hematopoietic Cell Transplantation Unit Hematology Department G. Papanikolaou Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lioure","sequence":"additional","affiliation":[{"name":"New Civil Hospital  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-2765","authenticated-orcid":false,"given":"Annalisa","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin","family":"Savani","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Spyridonidis","sequence":"additional","affiliation":[{"name":"University Hospital of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Sanz","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit Department of Hematology La Fe University and Polytechnic Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinaida","family":"Peric","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-1265","authenticated-orcid":false,"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"Hematology Division Chaim Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cellular Therapy National Institute of Health and Medical Research Unit UMR\u2010S 938 Sorbonne University and St Anthony Scientific Research Center Public Assistance Hospital of Paris St Anthony Hospital  Paris France"},{"name":"European Society for Blood and Marrow Transplantation Paris Study Office\/CEREST\u2010TC  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010018\u20100373\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010021\u201001227\u20108"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1703472"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1609337"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.10.2942"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(09)70225\u20106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(15)00462\u20103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.75.8177"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1506002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148510"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(19)30256\u2010x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.07.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.213"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.5.1303"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci124218"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201010\u2010525873"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006960"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100258(19990330)18:6<695::aid\u2010sim60>3.0.co;2\u2010o"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31354"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.11.003"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.02.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.06.019"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.08.014"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.247296"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010021\u201001094\u20102"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000487"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201000923\u20100"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018027003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010171463"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.07.023"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.271445"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003005"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201005\u2010780668"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24328"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004846"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010021\u201001364\u20100"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010019\u20100790\u2010x"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:39:56Z","timestamp":1760294396000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":39,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/cncr.35004"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35004","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2022-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}