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In the past year, there have been several advances in MF, PV, and essential thrombocythemia. In MF, investigational approaches are focusing on strategies to optimize inhibition of signal transduction (including JAK inhibition), modify epigenetics, enhance apoptosis, target DNA replication, transform host immunity, and\/or alter the tumor microenvironment. In PV, ropeginterferon alfa\u20102b has been introduced to the market in the United States, and data continue to accumulate to support the safety and efficacy of this treatment. Hepcidin mimesis is also emerging as a novel way to treat erythrocytosis. In essential thrombocythemia, ropeginterferon alfa\u20102b is being evaluated, as are therapies to modify epigenetics and inhibit CALR. The enhanced focus on MPNs brings hope that our field can improve morbidity and mortality in this group of diseases.<\/jats:p>","DOI":"10.1002\/cncr.35028","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T13:39:08Z","timestamp":1695908348000},"page":"3685-3691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Top advances of the year: Myeloproliferative neoplasms"],"prefix":"10.1002","volume":"129","author":[{"given":"Rupali R.","family":"Bhave","sequence":"first","affiliation":[{"name":"Section On Hematology and Medical Oncology Wake Forest University School of Medicine Atrium Health Wake Forest Baptist Comprehensive Cancer Center  Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Mesa","sequence":"additional","affiliation":[{"name":"Section On Hematology and Medical Oncology Wake Forest University School of 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