{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:53:12Z","timestamp":1793735592380,"version":"4.6.1"},"reference-count":46,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since the introduction of BCR::ABL1 tyrosine kinase inhibitors (TKIs) in 2000, the treatment of Philadelphia chromosome (Ph)\u2010positive chronic myeloid leukemia (CML) has improved significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study aimed to evaluate Ph\u2010positive CML outcomes in the TKI therapy era, considering factors like age, ethnicity, and income. Using the Surveillance, Epidemiology, and End Results (SEER) database, 2857 patients with Ph\u2010positive CML diagnosed from 2000 to 2019 were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall 5\u2010year survival rates in Ph\u2010positive CML increased to above 80%, compared with pre\u2010TKIs historical data reporting 5\u2010year overall survival (OS) rates of less than 50%. The 5\u2010year OS rate was 73% for patients diagnosed in 2000\u20132004, 82% in 2005\u20132009, and 78% in 2010\u20132014; the 4\u2010year OS rate was 83% in 2015\u20132019. The 5\u2010year OS rate for younger patients (&lt;60\u00a0years old) was 88% in 2000\u20132009 and 90% in 2010\u20132019 (<jats:italic>p<\/jats:italic> value .426). In older patients (60+ years old), the 5\u2010year OS rates were 64% and 65%, respectively (<jats:italic>p<\/jats:italic> value, .303). Lower household income was associated with inferior survival across the 2000\u20132019. These results are inferior to European studies where TKIs are universally available and affordable, and relative OS in CML is similar to age\u2010matched normal populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the outcome of Ph\u2010positive CML has improved significantly since 2000, the SEER data still shows differences in outcomes among patient subsets, some anticipated (worse OS in older patients accounted by the relative OS), but others that suggest less than universal access and affordability of this therapy (among poorer patients) in the United States.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35038","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T13:59:25Z","timestamp":1695909565000},"page":"3805-3814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Outcome of Philadelphia chromosome\u2010positive chronic myeloid leukemia in the United States since the introduction of imatinib therapy\u2014The Surveillance, Epidemiology, and End Results database, 2000\u20132019"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-0610","authenticated-orcid":false,"given":"Koji","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-8485","authenticated-orcid":false,"given":"Fadi G.","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-2738","authenticated-orcid":false,"given":"Nicholas J.","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Leukemia 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