{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:37:23Z","timestamp":1777160243625,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surveillance of high\u2010risk individuals for pancreatic ductal adenocarcinoma (PDAC) is recommended. This study aimed to determine the prevalence and outcomes of PDAC and its precursor lesions in <jats:italic>BRCA<\/jats:italic><jats:italic>1\/2<\/jats:italic> pathogenic variants (PVs) carriers undergoing pancreatic surveillance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective multicenter cohort study of pancreatic surveillance outcomes in Israeli <jats:italic>BRCA<\/jats:italic><jats:italic>1\/2<\/jats:italic> carriers preferably with a family history of PDAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 180 asymptomatic carriers participated in the screening programs, including 57 (31.7%) with <jats:italic>BRCA1<\/jats:italic> PVs, 121 (67.2%) with <jats:italic>BRCA2<\/jats:italic> PVs, and 12 (6.6%) with PVs in <jats:italic>BRCA1\/2<\/jats:italic> and other genes, for a median follow\u2010up period of 4\u00a0years. Ninety\u2010one individuals (50.5%) fulfilled the International Cancer of the Pancreas Screening (CAPS) criteria for surveillance whereas 116 (64.4%) fulfilled the American College of Gastroenterology (ACG) criteria. There were four cases of adenocarcinoma and four cases of grade 1\u2010neuroendocrine tumor (G1\u2010NET). All were <jats:italic>BRCA2<\/jats:italic> carriers, and two had no family history of PDAC. Three cancer patients were at resectable stages (IA, IIA, IIB) whereas one had a stage IIIB tumor. Of the G1\u2010NET cases, one had surgery and the others were only followed. Success rate for detection of confined pancreatic carcinoma was thus 1.6% (three of 180) in the whole cohort, 1.6% (two of 116) among individuals who fulfilled ACG criteria and 2.2% (two of 91) in those fulfilling CAPS criteria for surveillance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the low detection rate of PDAC and its' high\u2010risk neoplastic precursor lesions among <jats:italic>BRCA1\/2<\/jats:italic> carriers undergoing pancreatic surveillance, 75% of cancer cases were detected at a resectable stage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35052","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:23:38Z","timestamp":1697793818000},"page":"256-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The benefit of pancreatic cancer surveillance in carriers of germline <i>BRCA1\/2<\/i> pathogenic 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