{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:52:07Z","timestamp":1793411527477,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Support for health\u2010related quality of life (HRQOL) is an essential part of cancer care in the final stages of life, yet empirical guidance regarding HRQOL and symptom trajectories is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the change in HRQOL and symptom burden in the last year of life in patients with advanced cancer and its association with health care\u2013related factors, cancer\u2010specific treatment, and comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, multicenter, observational study in patients with advanced cancer (eQuiPe). Three monthly questionnaires included European Organization for Research and Treatment of Cancer Quality of Life\u2010C30 and reported continuity of care. Multivariable mixed\u2010effects analysis was used to assess the association between HRQOL and health care\u2013related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 762 deceased patients were included with a mean age of 66 (SD, 10) years and 52% were male. The most common primary tumors were lung (29%), colorectal (20%), and breast cancer (13%). Mean overall HRQOL decreased in the last 9\u00a0months of life, with the greatest decrease in the last 3\u00a0months (\u03b2 \u201316.2). Fatigue, pain, appetite loss, dyspnea, constipation, and nausea worsened significantly in the last year of life. Multimorbidity (\u03b2 \u20137.5) and a better reported continuity of care (\u03b2 0.7) were both significantly associated with the trajectory of HRQOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mean overall HRQOL begins to decline 9 months before death, highlighting the need for early identification and (re)assessment of different symptoms as aspects of HRQOL follow different trajectories. Multimorbidity and reported continuity of care may be associated with the trajectory of HRQOL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.35060","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:49:45Z","timestamp":1697204985000},"page":"609-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Trajectories of health\u2010related quality of life and symptom burden in patients with advanced cancer towards the end of life: Longitudinal results from the eQuiPe study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-294X","authenticated-orcid":false,"given":"Moyke A. J.","family":"Versluis","sequence":"first","affiliation":[{"name":"Research &amp; Development The Netherlands Comprehensive Cancer Organization (IKNL)  Utrecht The Netherlands"},{"name":"Graduate School of Social &amp; Behavioral Sciences Tilburg University  Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasja J. H.","family":"Raijmakers","sequence":"additional","affiliation":[{"name":"Research &amp; Development The Netherlands Comprehensive Cancer Organization (IKNL)  Utrecht The Netherlands"},{"name":"Netherlands Association for Palliative Care (PZNL)  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Baars","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Gelderse Vallei  Ede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke H. J.","family":"van den Beuken\u2010van Everdingen","sequence":"additional","affiliation":[{"name":"Centre of Expertise in Palliative Care Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"de Graeff","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6687-5393","authenticated-orcid":false,"given":"Mathijs P.","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Northwest Clinics  Alkmaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter K.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Hospital Gelderse Vallei  Ede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen S.","family":"Kloover","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Elisabeth\u2010Tweesteden Hospital  Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien J. M.","family":"Kuip","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Department of Anesthesiology, Pain and Palliative Care Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M. P. W.","family":"Mandigers","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Canisius\u2010Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirkje W.","family":"Sommeijer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Amsterdam University Medical Centre  Amsterdam The Netherlands"},{"name":"Department of Internal Medicine Flevoziekenhuis  Almere The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-6124","authenticated-orcid":false,"given":"Yvette M.","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Research &amp; Development The Netherlands Comprehensive Cancer Organization (IKNL)  Utrecht The Netherlands"},{"name":"Centre of Expertise in Palliative Care Leiden University Medical Centre  Leiden The Netherlands"},{"name":"Department of Radiotherapy Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonneke V.","family":"van de Poll\u2010Franse","sequence":"additional","affiliation":[{"name":"Research &amp; Development The Netherlands Comprehensive Cancer Organization (IKNL)  Utrecht The Netherlands"},{"name":"Department of Medical and Clinical Psychology CoRPS \u2013 Center for Research on Psychology in Somatic Diseases Tilburg University  Tilburg The Netherlands"},{"name":"Department of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization (WHO).Palliative care;2022. 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