{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:13:35Z","timestamp":1791929615018,"version":"4.3.4"},"reference-count":100,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fertility is a top concern for many survivors of cancer diagnosed as children, adolescents and young adults (CAYA). Fertility preservation (FP) treatments are effective, evidence\u2010based interventions to support their family building goals. Fertility discussions are a part of quality oncology care throughout the cancer care continuum. For nearly 2 decades, clinical guidelines recommend counseling patients about the possibility of infertility promptly at diagnosis and offering FP options and referrals as indicated. Multiple guidelines now recommend post\u2010treatment counseling. Infertility risks differ by cancer treatments and age, rendering risk stratification a central part of FP care. To support FP decision\u2010making, online tools for female risk estimation are available. At diagnosis, females can engage in mature oocyte\/embryo cryopreservation, ovarian tissue cryopreservation, ovarian suppression with GnRH agonists, in vitro oocyte maturation, and\/or conservative management for gynecologic cancers. Post\u2010treatment, several populations may consider undergoing oocyte\/embryo cryopreservation. Male survivors\u2019 standard of care FP treatments center on sperm cryopreservation before cancer treatment and do not have the same post\u2010treatment indication for additional gamete cryopreservation. In practice, FP care requires systemized processes to routinely screen for FP needs, bridge oncology referrals to fertility, offer timely fertility consultations and access to FP treatments, and support financial navigation. Sixteen US states passed laws requiring health insurers to provide insurance benefits for FP treatments, but variation among the laws and downstream implementation are barriers to accessing FP treatments. To preserve the reproductive futures of CAYA survivors, research is needed to improve risk stratification, FP options, and delivery of FP care.<\/jats:p>","DOI":"10.1002\/cncr.35108","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T07:45:17Z","timestamp":1699947917000},"page":"344-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Fertility preservation before and after cancer treatment in children, adolescents, and young adults"],"prefix":"10.1002","volume":"130","author":[{"given":"Emily H.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmonie B.","family":"Strohl","sequence":"additional","affiliation":[{"name":"School of Medicine University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Irene","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics, Gynecology and Reproductive Sciences Moores Cancer Center University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"American Cancer Society.Cancer Facts & Figures 2022. Accessed December 20 2022.https:\/\/www.cancer.org\/content\/dam\/cancer\u2010org\/research\/cancer\u2010facts\u2010and\u2010statistics\/annual\u2010cancer\u2010facts\u2010and\u2010figures\/2022\/2022\u2010cancer\u2010facts\u2010and\u2010figures.pdf"},{"key":"e_1_2_13_3_1","unstructured":"American Cancer Society.Cancer Facts & Figures 2020\u2010Special Section: Cancer in Adolescents and Young Adults.2023.https:\/\/www.cancer.org\/content\/dam\/cancer\u2010org\/research\/cancer\u2010facts\u2010and\u2010statistics\/annual\u2010cancer\u2010facts\u2010and\u2010figures\/2020\/special\u2010section\u2010cancer\u2010in\u2010adolescents\u2010and\u2010young\u2010adults\u20102020.pdf"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29328"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32932"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_279787"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29133"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010017\u20104006\u2010z"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4927"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.1914"},{"key":"e_1_2_13_11_1","unstructured":"Children\u2019s Oncology Group.Children\u2019s Oncology Group Long\u2010Term Guidelines for Survivors of Childhood Adolescent and Young Adult Cancersversion 5.0 \u2010 October 2018. Accessed 30 March 30 2020.http:\/\/www.survivorshipguidelines.org\/pdf\/2018\/COG_LTFU_Guidelines_v5.pdf"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.013"},{"key":"e_1_2_13_13_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology: Adolescent and Young Adult (AYA) Oncology. Accessed July 1 2023.https:\/\/www.nccn.org\/professionals\/physician_gls\/default.aspx#age"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.038"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23071"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/1464727022000198942"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301143280203"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010015\u20100457\u20108"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010018\u20100695\u20107"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(16)00086\u20103"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26403"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(13)70251\u20101"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab036"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(92)91335\u20108"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj243"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00722"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978\u2010022\u201001559\u20108"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30594\u20105"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016\u20103723"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(19)30818\u20106"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2020.0012"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24679"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.01.016"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1530\/RAF\u201022\u20100020"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz008"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.02.028"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.09.002"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey229"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa172"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.2307\/3574084"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201018\u20100221"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey240"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.03.367"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad097"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010016\u20102236\u2010y"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010014\u20100354\u20106"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.6938"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30026\u20108"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.08.010"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4927"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2014.932790"},{"key":"e_1_2_13_52_1","unstructured":"Childhood Cancer Survivor Study.Acute Ovarian Failure Risk Prediction Calculator.2023. Accessed July 1 2023.https:\/\/ccss.stjude.org\/tools\u2010documents\/calculators\u2010other\u2010tools\/ccss\u2010ovarian\u2010risk\u2010calculator.html"},{"key":"e_1_2_13_53_1","unstructured":"Childhood Cancer Survivor Study.Premature Ovarian Insufficiency Calculator.2023. Accessed July 1 2023.https:\/\/ccss.stjude.org\/tools\u2010documents\/calculators\u2010other\u2010tools\/primary\u2010ovarian\u2010insufficiency\u2010risk\u2010calculator.html"},{"key":"e_1_2_13_54_1","unstructured":"University of California San Diego AYA Cancer Survivor Research Team.Cancer Related Infertility Score Predictor.2023. Accessed July 1 2023.https:\/\/oncofertilityrisk.com\/"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.3288"},{"key":"e_1_2_13_56_1","unstructured":"Food and Drug Administration.Guidance for Industry1 Reproductive and Developmental Toxicities \u2014 Integrating Study Results to Assess ConcernsAccessed July 1 2023 2023.https:\/\/www.fda.gov\/media\/72231\/download"},{"key":"e_1_2_13_57_1","volume-title":"2020 Assisted Reproductive Technology Fertility Clinic and National Summary Report","author":"Centers for Disease Control and Prevention","year":"2022"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac249"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.6.559"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac145"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac035"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.03.008"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.0858"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab213"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.11.018"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0b013e31827a0643"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.01.003"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmab041"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2020.10.013"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.06.032"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2017.18.8.2083"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010019\u20100520\u20106"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13051008"},{"issue":"3","key":"e_1_2_13_74_1","first-page":"235","article-title":"Laparoscopic ovarian transposition and ovariopexy for fertility preservation in patients treated with pelvic radiotherapy with or without chemotherapy","volume":"11","author":"Turkgeldi L","year":"2019","journal-title":"Facts Views Vis Obgyn"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010022\u201001887\u20108"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.04.002"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.12.041"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.12.009"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.10.026"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey321"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.03.029"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010019\u201001462\u20105"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.08.010"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.016"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.013"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010021\u201002376\u2010x"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.08.035"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac004"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.574263"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.7808"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010020\u201001697\u20107"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.10806"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy038"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2021.0224"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2023.107215"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010022\u201001280\u20102"},{"key":"e_1_2_13_97_1","unstructured":"California Health Benefits Review Program.Analysis of Senate Bill (SB) 600: Fertility Preservation. A report to the 2019\u20102020 California State Legislature.2019. Accessed June 15 2023.http:\/\/analyses.chbrp.com\/document\/view.php?id=1407"},{"key":"e_1_2_13_98_1","unstructured":"Alliance for Fertility Preservation. State Laws and Legislation.2023. Accessed June 15 2023 https:\/\/www.allianceforfertilitypreservation.org\/advocacy\/state\u2010legislation"},{"key":"e_1_2_13_99_1","volume-title":"Mandated health insurance benefits: tradeoffs among benefits, coverage and costs?","author":"Cubanski J","year":"2002"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2021.4309"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.05.034"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:43:00Z","timestamp":1760262180000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":100,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cncr.35108"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35108","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,14]]},"assertion":[{"value":"2023-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}