{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:45:27Z","timestamp":1784198727667,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"S8","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Taxanes are the basic components of breast cancer chemotherapy. Nanoparticle albumin\u2010bound paclitaxel (nab\u2010paclitaxel) shows improved antitumor effects because of more targeted delivery. However, the effects of nab\u2010paclitaxel have not been systematically studied in patients with metastatic breast cancer (MBC) pretreated with taxanes. Considering the limited treatment options for MBC, this study retrospectively evaluated the clinical efficacy and adverse effects of nab\u2010paclitaxel in patients with taxane\u2010pretreated MBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who had previously received taxanes and subsequently received nab\u2010paclitaxel chemotherapy for MBC at Jiangsu Cancer Hospital between October 2014 and April 2022 were included for analysis. The primary end point was progression\u2010free survival (PFS), and the secondary end points were the objective response rate (ORR), disease control rate (DCR), clinical benefit rate (CBR), and side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 236 female patients with MBC were included. The median PFS was 7.20\u00a0months (95% confidence interval [CI], 6.63\u20137.80\u00a0months), and the ORR, DCR, and CBR were 29.55% (95% CI, 23.50%\u201335.60%), 83.64% (95% CI, 78.70%\u201388.60%), and 56.36% (95% CI, 49.80%\u201363.00%), respectively. Following nab\u2010paclitaxel treatment, the median PFS of patients who were sensitive to taxanes during previous treatments was significantly longer than that of patients who were resistant to taxanes (7.57\u00a0months vs. 4.43\u00a0months, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The most common adverse events were sensory neuropathy (89.83%), neutropenia (48.73%), leukopenia (46.61%), and anemia (35.59%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nab\u2010paclitaxel demonstrated clinical activity in taxane\u2010pretreated patients with MBC. This beneficial effect was observed both in patients who were sensitive and resistant to taxanes during previous treatments. These results suggest nab\u2010paclitaxel as the preferred chemotherapy regimen in patients with MBC, regardless of their sensitivity to taxanes during previous treatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35206","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T13:33:50Z","timestamp":1706189630000},"page":"1488-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of nanoparticle albumin\u2010bound paclitaxel in taxane\u2010pretreated metastatic breast cancer patients"],"prefix":"10.1002","volume":"130","author":[{"given":"Weili","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Oncology The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2138-0572","authenticated-orcid":false,"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemotherapy Jiangsu Cancer Hospital &amp; 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