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There are no prospective clinical trials evaluating safety and efficacy of direct oral anticoagulants (DOACs), specifically in patients with BT, but they are widely used for VTE in this population. A group of neuro\u2010oncology experts convened to provide practical clinical guidance for the off\u2010label use of DOACs in treating VTE in patients with BT. We searched PubMed for the following terms: BTs, glioma, glioblastoma (GBM), brain metastasis, VTE, heparin, low\u2010molecular\u2010weight heparin (LWMH), DOACs, and ICH. 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