{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:58:59Z","timestamp":1786370339527,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to explore the abilities of atezolizumab plus chemotherapy in preventing brain metastases (BMs) among metastatic non\u2013small cell lung cancer (NSCLC) without initial BMs, as well as the risk factors of BMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individual patient data from three trials involving first\u2010line atezolizumab for metastatic NSCLC (IMpower130, IMpower131, and IMpower150) were pooled. Among patients without baseline BMs and without <jats:italic>epidermal growth factor receptor<\/jats:italic>\u00a0(<jats:italic>EGFR<\/jats:italic>) and\/or <jats:italic>anaplastic lymphoma kinase<\/jats:italic> (<jats:italic>ALK<\/jats:italic>) mutations, those receiving atezolizumab\u00a0+\u00a0chemotherapy\u00a0\u00b1\u00a0bevacizumab were classified as the atezolizumab\u00a0plus chemotherapy group and those receiving placebo\u00a0+\u00a0chemotherapy\u00a0\u00b1\u00a0bevacizumab were classified as the chemotherapy group. The cumulative incidences of BM (CI\u2010BMs) between the two groups were compared. Other factors associated with the CI\u2010BM were analyzed by Cox regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median follow\u2010up of 17.6 months (range, 0.03\u201333.64 months), 74 (3.1%) of the 2380 enrolled patients developed BMs, including 50 (3.1%) and 24 (3.0%) in the atezolizumab plus chemotherapy group (<jats:italic>n<\/jats:italic>\u00a0=\u00a01589) and the chemotherapy group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0791), respectively. The CI\u2010BMs at 6, 12, and 24\u00a0months were 1.7%, 2.8%, and 3.3%, respectively. After taking competing risk events into account, there was no significant difference in the CI\u2010BMs between the two groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.888). Nevertheless, the use of bevacizumab and the histology of nonsquamous NSCLC were found to be independently associated with the risk of BMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with metastatic <jats:italic>EGFR<\/jats:italic>\/<jats:italic>ALK<\/jats:italic> wild\u2010type NSCLC without baseline BMs, adding atezolizumab in the first\u2010line treatment might not reduce the CI\u2010BM. However, the administration of bevacizumab may reduce the risk of BMs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35242","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T08:14:01Z","timestamp":1707898441000},"page":"2601-2610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cumulative incidence and risk factors of brain metastases in metastatic non\u2013small cell lung cancer without baseline brain metastasis: Pooled analysis of individualized patient data from IMpower130, IMpower131, and IMpower150"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-4270","authenticated-orcid":false,"given":"Yue","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4184-7844","authenticated-orcid":false,"given":"Fei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai China"},{"name":"Department of Cancer Prevention Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjiao","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-3619","authenticated-orcid":false,"given":"Zhengfei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai China"},{"name":"Institute of Thoracic Oncology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25183"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2017.04.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.03.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1606774"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1917346"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(21)00228\u20102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1910231"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1801005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1810865"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1716948"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(20)30641\u20100"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(16)32517\u2010x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/cmr.0000000000000700"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmp1605348"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(19)30167\u20106"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.03.028"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.12.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/po.22.00220"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.21.25787"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2017.06.022"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.04.004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz207"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.10.128"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.cd\u201014\u20101129"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.829451"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201000872\u20109"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa028"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.09.276"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.07.005"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201008449\u2010w"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000012642"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1179\/1973947815y.0000000045"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.mct\u201015\u20100582"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010019\u20100974\u20106"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.01.007"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102021\u20100103"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab101"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.07.011"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:08:34Z","timestamp":1760263714000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,14]]},"references-count":40,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/cncr.35242"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35242","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,14]]},"assertion":[{"value":"2023-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}