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We analyzed the characteristics of BTC\u2010related hospitalizations under medical services across 28 hospitals in Ontario, Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study uses data collected by GEMINI, a hospital research data network. BTC\u2010related hospitalizations from 2015 to 2021 under the Department of Medicine or intensive care unit were captured using the International Classification of Diseases, 10th revision, codes for intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma, and gallbladder cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4596 BTC\u2010related hospitalizations (2720 iCCA, 1269 extrahepatic cholangiocarcinoma, 607 gallbladder cancers) were analyzed. The number of unique patients with BTC\u2010related hospitalizations increased over time. For iCCA\u2010related hospitalizations, the total number of hospitalizations increased (from 385 in 2016 to 420 in 2021, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005), the hospital length of stay decreased over the study period (mean 10\u00a0days [SD, 12] in 2016 to 9\u00a0days [SD, 8] in 2021, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04), and the number of in\u2010hospital deaths was stable (from 68 [18%] in 2016 to 55 [13%] in 2021, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.62). Other outcomes such as 30\u2010day readmissions, medical imaging tests, intensive care unit\u2013specific hospitalizations, and length of stay were stable over time for all cohorts. The cost of hospitalization for the BTC cohort increased from median $8203 CAD (interquartile range, 5063\u201315,543) in 2017 to $8507 CAD (interquartile range, 5345\u201314,755) in 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This real\u2010world data analysis showed a rising number of patients with BTC\u2010related hospitalizations and rising number of iCCA\u2010related hospitalizations across 28 hospitals in Ontario between 2015 and 2021.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35249","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T02:49:00Z","timestamp":1708051740000},"page":"2294-2303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing the burden of biliary tract cancers across 28 hospitals in Ontario, Canada"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-6500","authenticated-orcid":false,"given":"Woo Jin","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Surgery University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute St Michael\u2019s Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surain","family":"Roberts","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute St Michael\u2019s Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol","family":"Verma","sequence":"additional","affiliation":[{"name":"Li Ka Shing Knowledge Institute St Michael\u2019s Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Razak","sequence":"additional","affiliation":[{"name":"Li Ka Shing Knowledge Institute St Michael\u2019s Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grainne M.","family":"O\u2019Kane","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Trinity St. James's Cancer Institute Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Toronto  Toronto Ontario Canada"},{"name":"University Health Network HPB Surgical Oncology  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Hirschfield","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Toronto Centre for Liver Disease Toronto General Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Hansen","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Toronto Centre for Liver Disease Toronto General Hospital University Health Network  Toronto Ontario Canada"},{"name":"Department of Epidemiology &amp; 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