{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:42:01Z","timestamp":1787510521739,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to investigate the role of clinical factors together with\n                      <jats:italic>FOXO1<\/jats:italic>\n                      fusion status in patients with nonmetastatic rhabdomyosarcoma (RMS) to develop a predictive model for event\u2010free survival and provide a rationale for risk stratification in future trials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The authors used data from patients enrolled in the European\n                      <jats:italic>Pediatric<\/jats:italic>\n                      Soft Tissue Sarcoma Study Group (E\n                      <jats:italic>p<\/jats:italic>\n                      SSG) RMS 2005 study (E\n                      <jats:italic>p<\/jats:italic>\n                      SSG RMS 2005; EudraCT number 2005\u2010000217\u201035). The following baseline variables were considered for the multivariable model: age at diagnosis, sex, histology, primary tumor site, Intergroup Rhabdomyosarcoma Studies group, tumor size, nodal status, and\n                      <jats:italic>FOXO1<\/jats:italic>\n                      fusion status. Main effects and significant second\u2010order interactions of candidate predictors were included in a multiple Cox proportional hazards regression model. A nomogram was generated for predicting 5\u2010year event\u2010free survival (EFS) probabilities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The EFS and overall survival rates at 5\u00a0years were 70.9% (95% confidence interval, 68.6%\u201373.1%) and 81.0% (95% confidence interval, 78.9%\u201382.8%), respectively. The multivariable model retained five prognostic factors, including age\u00a0at diagnosis interacting with tumor size, tumor primary site, Intergroup Rhabdomyosarcoma Studies clinical group, and\n                      <jats:italic>FOXO1<\/jats:italic>\n                      fusion status. Based on each patient's total score in the nomogram, patients were stratified into four groups. The 5\u2010year EFS rates were 94.1%, 78.4%, 65.2%, and 52.1% in the low\u2010risk, intermediate\u2010risk, high\u2010risk, and very\u2010high\u2010risk groups, respectively, and the corresponding 5\u2010year overall survival rates were 97.2%, 91.5%, 74.3%, and 60.8%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results presented here provide the rationale to modify the E\n                      <jats:italic>p<\/jats:italic>\n                      SSG stratification, with the most significant change represented by the replacement of histology with fusion status. This classification was adopted in the new international trial launched by the E\n                      <jats:italic>p<\/jats:italic>\n                      SSG.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.35258","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T06:24:15Z","timestamp":1708755855000},"page":"2351-2360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Reappraisal of prognostic factors used in the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 study for localized rhabdomyosarcoma to optimize risk stratification and generate a prognostic nomogram"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-8476","authenticated-orcid":false,"given":"Gian Luca","family":"De Salvo","sequence":"first","affiliation":[{"name":"Clinical Research Unit Istituto Oncologico Veneto\u2013IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6597-0265","authenticated-orcid":false,"given":"Paola","family":"Del Bianco","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Istituto Oncologico Veneto\u2013IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Minard\u2010Colin","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 1015 Gustave\u2010Roussy Universit\u00e9 Paris\u2010Saclay  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Children and Young People's Unit Royal Marsden Hospital and Institute of Cancer Research  Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriel","family":"Jenney","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Children\u2019s Hospital for Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Guillen","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Oncology Unit Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Devalck","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire des Enfants Reine Fabiola Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Van Rijn","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Emma Children's Hospital Amsterdam University Medical Center University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Shipley","sequence":"additional","affiliation":[{"name":"Sarcoma Molecular Pathology Team Divisions of Molecular Pathology and Cancer Therapeutics The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-139X","authenticated-orcid":false,"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[{"name":"SIREDO Oncology Center Institut Curie Paris Sciences et Lettres University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Department of Pediatric Histopathology Manchester University Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery University Hospitals Bristol and Weston National Health Service Foundation Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-3745","authenticated-orcid":false,"given":"Florent","family":"Guerin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgical Oncology University Hospital Bic\u011btre  Le Kremlin\u2010Bicetre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scarzello","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit Istituto Oncologico Veneto\u2013IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4724-0517","authenticated-orcid":false,"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale Tumori  Milan 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