{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:54:41Z","timestamp":1777906481017,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Both venetoclax plus a hypomethylating agent (VEN\/HMA) and cytarabine, aclarubicin, and granulocyte colony\u2010stimulating factor (CAG) are low\u2010intensity regimens for older patients with acute myeloid leukemia (AML) that show good efficacy and safety. It is unknown how VEN\/HMA compares with the CAG regimen for the treatment of newly diagnosed AML.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The outcomes of patients with newly diagnosed AML treated with VEN\/HMA were compared with those of patients treated with a CAG\u2010based regimen. Propensity score matching between these two cohorts at a 1:1 ratio was performed according to age at diagnosis, sex, Eastern Cooperative Oncology Group performance status, state of fitness, and European LeukemiaNet (ELN) 2022 risk stratification to minimize bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 84 of 96 patients in the VEN\/HMA cohort were matched with 84 of 147 patients in the CAG cohort. VEN\/HMA resulted in a better response than the CAG\u2010based regimens, as indicated by a higher composite complete remission (CRc) rate (82.1% vs. 60.7%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) and minimal residual disease negativity rate (88.2% vs. 68.2%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009). In patients with an ELN adverse risk, VEN\/HMA was associated with a higher CRc rate compared to CAG (80.5% vs. 58.3%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006). VEN\/HMA was associated with longer event\u2010free survival (EFS) (median EFS, not reached vs. 4.5 months; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0004), whereas overall survival (OS) was comparable between the two cohorts (median OS, not reached vs. 18 months; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.078).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The VEN\/HMA regimen may result in a better response than CAG\u2010based treatment in older patients with newly diagnosed AML.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35278","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T11:05:28Z","timestamp":1710241528000},"page":"2472-2481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Venetoclax plus a hypomethylating agent versus cytarabine, aclarubicin, and granulocyte colony\u2010stimulating factor chemotherapy as a first\u2010line therapy for newly diagnosed acute myeloid leukemia: A propensity score\u2013matched analysis"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3048-2835","authenticated-orcid":false,"given":"Rui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology Zhujiang Hospital of Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghua","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Guangdong Medical University  Zhanjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First People\u2019s Hospital of Foshan  Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhujiang Hospital of Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Hematology Maoming People\u2019s Hospital  Maoming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First People\u2019s Hospital of Zhaoqing  Zhaoqing 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