{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:09:17Z","timestamp":1789132157958,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR004419"],"award-info":[{"award-number":["UL1TR004419"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA203193"],"award-info":[{"award-number":["R01CA203193"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many patients with early\u2010stage lung cancer are not candidates for lobectomy because of various factors, with treatment options including sublobar resection or stereotactic body radiation therapy (SBRT). Limited information exists regarding patient\u2010centered outcomes after these treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects with stage I\u2013IIA non\u2013small cell lung cancer (NSCLC) at high risk for lobectomy who underwent treatment with sublobar resection or SBRT were recruited from five medical centers. Quality of life (QOL) was compared with the Short Form 8 (SF\u20108) for physical and mental health and Functional Assessment of Cancer Therapy\u2013Lung (FACT\u2010L) surveys at baseline (pretreatment) and 7 days, 30 days, 6 months, and 12 months after treatment. Propensity score methods were used to control for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 337 subjects enrolled before treatment, 63% received SBRT. Among patients undergoing resection, 89% underwent minimally invasive video\u2010assisted thoracic surgery or robot\u2010assisted resection. Adjusted analyses showed that SBRT\u2010treated patients had both higher physical health SF\u20108 scores (difference in differences [DID], 6.42; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0008) and FACT\u2010L scores (DID, 2.47; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) at 7 days posttreatment. Mental health SF\u20108 scores were not different at 7 days (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.06). There were no significant differences in QOL at other time points, and all QOL scores returned to baseline by 12 months for both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SBRT is associated with better QOL immediately posttreatment compared with sublobar resection. However, both treatment groups reported similar QOL at later time points, with a return to baseline QOL. These findings suggest that sublobar resection and SBRT have a similar impact on the QOL of patients with early\u2010stage lung cancer deemed ineligible for lobectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35286","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T05:28:52Z","timestamp":1710998932000},"page":"2515-2527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Longitudinal quality of life after sublobar resection and stereotactic body radiation therapy for early\u2010stage non\u2013small cell lung cancer"],"prefix":"10.1002","volume":"130","author":[{"given":"Juan P.","family":"Wisnivesky","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-9041","authenticated-orcid":false,"given":"Jeremy","family":"Mudd","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Stone","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Slatore","sequence":"additional","affiliation":[{"name":"Division of Pulmonary &amp; 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