{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:46:24Z","timestamp":1789847184258,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"S8","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Studies on various thrombopoietic agents for cancer treatment\u2013induced thrombocytopenia (CTIT) in China are lacking. This study aimed to provide detailed clinical profiles to understand the outcomes and safety of different CTIT treatment regimens.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this retrospective, cross\u2010sectional study, 1664 questionnaires were collected from 33 hospitals between March 1 and July 1, 2021. Patients aged >18 years were enrolled who were diagnosed with CTIT and treated with recombinant interleukin 11 (rhIL\u201011), recombinant thrombopoietin (rhTPO), or a thrombopoietin receptor agonist (TPO\u2010RA). The outcomes, compliance, and safety of different treatments were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 1437 analyzable cases, most patients were treated with either rhTPO alone (49.3%) or rhIL\u201011 alone (27.0%). The most common combination regimen used was rhTPO and rhIL\u201011 (10.9%). Platelet transfusions were received by 117 cases (8.1%). In multivariate analysis, rhTPO was associated with a significantly lower proportion of platelet recovery, platelet transfusion, and hospitalization due to chemotherapy\u2010induced thrombocytopenia (CIT) than rhIL\u201011 alone. No significant difference was observed in the time taken to achieve a platelet count of >100\u00a0\u00d7\u00a0109<\/jats:sup>\/L and chemotherapy dose reduction due to CIT among the different thrombopoietic agents. The outcomes of thrombocytopenia in 170 patients who received targeted therapy and\/or immunotherapy are also summarized. The results show that the proportion of platelet recovery was similar among the different thrombopoietic agents. No new safety signals related to thrombopoietic agents were observed in this study. A higher proportion of physicians preferred to continue treatment with TPO\u2010RA alone than with rhTPO and rhIL\u201011.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This survey provides an overview of CTIT and the application of various thrombopoietic agents throughout China. Comparison of monotherapy with rhIL\u201011, rhTPO, and TPO\u2010RA requires further randomized clinical trials. The appropriate application for thrombopoietic agents should depend on the pretreatment of platelets, treatment variables, and risk of bleeding.<\/jats:p><\/jats:sec>Plain Language Summary<\/jats:title>\n\nTo provide an overview of the outcome of cancer treatment\u2013induced thrombocytopenia in China, our cross\u2010sectional study analyzed 1437 cases treated with different thrombopoietic agents.<\/jats:p><\/jats:list-item>\nMost of the patients were treated with recombinant interleukin 11 (rhIL\u201011) and recombinant thrombopoietin (rhTPO).<\/jats:p><\/jats:list-item>\nrhTPO was associated with a significantly lower proportion of platelet recovery and platelet transfusion compared with rhIL\u201011.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35292","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T03:31:30Z","timestamp":1711078290000},"page":"1524-1538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A real\u2010world observation on thrombopoietic agents for patients with cancer treatment\u2013induced thrombocytopenia in China: A multicenter, cross\u2010sectional study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-1300","authenticated-orcid":false,"given":"Meiting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Oncology Renji Hospital Medical College of Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Chen","sequence":"additional","affiliation":[{"name":"Departement of Oncology The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Liao","sequence":"additional","affiliation":[{"name":"Departement of Medical Oncology Shaanxi Cancer Hospital Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cancer Center First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangsu Cancer Institute Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Internal Medicine Affiliated Cancer Hospital and Institute of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Harbin Medical University Cancer Hospital Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Harbin Medical University Cancer Hospital Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine Department of Radiation Oncology The First Affiliated Hospital of University of Science and Technology of China Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Oncology Cancer Center of Union Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3558-8572","authenticated-orcid":false,"given":"Cong","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-5511","authenticated-orcid":false,"given":"Xin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Internal Medicine Sichuan Cancer Hospital and Institute Sichuan Cancer Center School of Medicine University of Electronic Science and Technology of China Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangsheng","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Hou","sequence":"additional","affiliation":[{"name":"Lung Cancer Center West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology Zhejiang Cancer Hospital Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Internal Medicine First People's Hospital of Foshan Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University Medical College Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincai","family":"Zhong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medicine University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Cancer Center of Union Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqian","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangsu Province Hospital Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hunan Cancer Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tianjin People's Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology Yunnan Cancer Hospital The Third Affiliated Hospital of Kunming Medical College Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Clinical Research Center for Cancer Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Internal Medicine Cancer Hospital of the Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjun","family":"Liao","sequence":"additional","affiliation":[{"name":"Internal Medicine\u2010Oncology Southern Medical University Nanfang Hospital Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"The Second Department of Oncology Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Fujian Provincial Cancer Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fuzhou General Hospital of Nanjing Military Command Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Shenzhen People's Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-8413","authenticated-orcid":false,"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Cancer 1 Cancer Hospital of China Medical University Liaoning Cancer Hospital and Institute Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangsu Cancer Institute Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ba","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Clinical Research Center for Cancer Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5414-8049","authenticated-orcid":false,"given":"Yanxia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279512"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010019\u20105354\u20105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12758"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.06.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e318210e685"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00775"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201003\u20101173"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672\u2010023\u201000616\u20103"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0026"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2021.1924053"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.701539"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(22)00001\u20101"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.18.01931"},{"issue":"9","key":"e_1_2_9_15_1","first-page":"714","article-title":"Consensus on clinical diagnosis, treatment and prevention management of chemotherapy induced thrombocytopenia in China (2018)","volume":"40","author":"Consensus Committee of Chemotherapy Induced Thrombocytopenia, Chinese Society of Clinical Oncology","year":"2018","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.03.012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.13152"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.260125"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/11594310\u2010000000000\u201000000"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.11.020"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13595"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.76.1734"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.251900"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1459605"},{"key":"e_1_2_9_25_1","first-page":"3607","article-title":"A randomized placebo\u2010controlled trial of recombinant human interleukin\u201011 in cancer patients with severe thrombocytopenia due to chemotherapy","volume":"87","author":"Tepler I","year":"1996","journal-title":"Blood"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010019\u201004734\u2010z"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010132\u20105\u2010200003070\u201000005"},{"issue":"4","key":"e_1_2_9_28_1","first-page":"437","article-title":"A multi\u2010center clinical trial of recombinant human thrombopoietin in the treatment of chemotherapy\u2010induced thrombocytopenia in patients with solid tumor","volume":"26","author":"Bai C","year":"2004","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd012035.pub2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257673"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201021\u20102763"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.12659\/ajcr.927008"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001461\u20102"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010020\u20106708\u20108"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201014\u20102093"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201016\u20100939"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.746707"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201021\u2010464"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.694409"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:22:52Z","timestamp":1760293372000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":38,"journal-issue":{"issue":"S8","published-print":{"date-parts":[[2024,4,15]]}},"alternative-id":["10.1002\/cncr.35292"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35292","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,22]]},"assertion":[{"value":"2023-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}