{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:12:46Z","timestamp":1790878366647,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tocilizumab is commonly used for the management of chimeric antigen receptor (CAR) T\u2010cell therapy\u2013associated cytokine release syndrome (CRS). However, it remains unknown whether tocilizumab or its dosage affects the efficacy and safety of CAR T\u2010cell therapy. The objective of this multicenter retrospective study was to explore the impact of tocilizumab on CAR T\u2010cell therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 93 patients with B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) receiving humanized anti\u2010CD19 CAR T cells were recruited from May 2016 to November 2022. Forty\u2010five patients received tocilizumab (tocilizumab group), whereas 48 patients did not (nontocilizumab group). Thirteen patients received &gt;1 dose of tocilizumab. The primary end point was the effect of tocilizumab on the efficacy and safety of CAR T cells. Additionally, proliferation, killing, and cytokine assays of CAR T cells were performed in vitro in the presence of tocilizumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age of the patients was 33 years, with 47 males and 46 females. Patients in the tocilizumab group showed similar complete response (CR) rate, overall survival (OS), and event\u2010free survival (EFS) compared with the nontocilizumab group. Compared with patients who received \u22641 dose of tocilizumab, receiving &gt;1 dose of tocilizumab did not affect their CR rate, OS, or EFS. In the tocilizumab group, all patients experienced CRS and 26.7% experienced immune\u00a0effector cell\u2013associated neurotoxicity syndrome (ICANS). In the nontocilizumab group, 64.6% of patients experienced CRS and 8.3% experienced ICANS. Up to 75% of ICANS and 87.5% of grade \u22653 ICANS occurred in the tocilizumab group. In vitro, tocilizumab did not impair the proliferation and killing effects of CAR T cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tocilizumab does not affect the efficacy of CAR T cells but may increase the likelihood of ICANS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.35316","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T13:43:18Z","timestamp":1712324598000},"page":"2660-2669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of tocilizumab on anti\u2010CD19 chimeric antigen receptor T\u2010cell therapy in B\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-7228","authenticated-orcid":false,"given":"Xiangmin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingpei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianci","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital of Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aibin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital of Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-5835","authenticated-orcid":false,"given":"Wei","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Blood Diseases Institute Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201011\u2010883710"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013733"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26506"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1709919"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009098"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899\u2010018\u20100470\u2010x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042150"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2595"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425\u2010018\u20100343\u20109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17527"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2020.1729735"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1407222"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1707447"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001463"},{"key":"e_1_2_9_16_1","first-page":"83","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview","volume":"102","author":"Sabattini E","year":"2010","journal-title":"Pathologica"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0042"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25108"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666x.2019.1629904"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008865"},{"key":"e_1_2_9_22_1","first-page":"705","article-title":"Spotlight on tocilizumab in the treatment of CAR\u2010T\u2010cell\u2010induced cytokine release syndrome: clinical evidence to date","volume":"16","author":"Si S","year":"2020","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.745320"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1709866"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.cd\u201017\u20100698"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010021\u201000547\u20106"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010021\u201002148\u20106"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01973"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201005\u2010552729"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v130.suppl_1.1547.1547"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102020\u2010143114"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/10781552221140320"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s41437"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m111.295758"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.914959"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:08:46Z","timestamp":1760263726000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":34,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/cncr.35316"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35316","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]},"assertion":[{"value":"2024-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}