{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:51Z","timestamp":1786977531634,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sexual dysfunction is a significant complication of treatment for many adult\u2010onset cancers. However, comparatively less is known about sexual dysfunction in adult childhood cancer survivors (CCSs). Research has been limited by the exclusion of specific cancers (e.g., central nervous system [CNS] tumors) and the lack of validated measures, which makes it difficult to understand the nature and prevalence of sexual dysfunction in CCSs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 249 adult CCSs (aged 18\u201365 years) enrolled in Project REACH, a prospective cohort study, and completed measures of physical and mental health, including sexual dysfunction. Participants scoring \u226419 on the Female Sexual Function Index 6 or \u226421 on the International Index of Erectile Function 5 were classified as experiencing sexual dysfunction. Analyses examined the relationships between sexual dysfunction and demographic, disease, treatment, and health variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 78 participants (32%) experienced clinically significant sexual dysfunction. In univariate analysis, sexual dysfunction was significantly associated with CNS tumor diagnosis (odds ratio [OR],\u00a02.56) and surgery (OR,\u00a01.96) as well as with health variables such as fatigue (OR,\u00a03.00), poor sleep (OR,\u00a02.84), pain (OR,\u00a02.04), depression (OR,\u00a02.64), poor physical health (OR,\u00a02.45), and poor mental health (OR,\u00a02.21). Adjusted analyses found that CNS tumor diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001) and health variables (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.025) contribute significantly to sexual dysfunction in CCSs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately one third of adult CCSs report clinically significant sexual dysfunction, which underscores a significant screening and treatment need. However, because available measures were developed for survivors of adult cancers, research to create a sexual health measure specifically for adult CCSs is necessary to better identify the sexual health concerns of this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.35363","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T08:48:15Z","timestamp":1716886095000},"page":"3023-3033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sexual health in adult survivors of childhood cancer: A Project REACH study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-4198","authenticated-orcid":false,"given":"Lydia L.","family":"Chevalier","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Department of Psychosocial 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