{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:55:07Z","timestamp":1791327307749,"version":"4.3.1"},"reference-count":52,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal choice for graft\u2010versus\u2010host disease (GVHD) prophylaxis in haploidentical stem cell transplantation (haplo\u2010SCT) remains debatable. Posttransplant cyclophosphamide (PTCy) and anti\u2010thymocyte globulin (ATG) are two common strategies, but little is known about their combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using the European Society for Blood and Marrow Transplantation (EBMT) registry, the authors identified 3649 adult patients with acute myeloid leukemia (AML) who underwent haplo\u2010SCT in complete remission between 2007 and 2021 at 260 EBMT\u2010participating centers who received either PTCy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02999), ATG (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0358), or combination prophylaxis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0292). Cord blood transplants, combined bone marrow and peripheral grafts, and transplants with ex vivo graft manipulation were excluded. Median follow\u2010up was 31.8 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On multivariate analysis, adjusting for patient age and performance status, disease status at transplant, cytogenetic risk, conditioning intensity, stem cell source, female\u2010to\u2010male graft, and donor and patient CMV status, we present the following. Compared to PTCy, ATG had a higher risk of nonrelapse mortality (hazard ratio [HR], 1.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003), worse leukemia\u2010free survival (HR, 1.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002), overall survival (HR,\u00a01.49;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0009), and GVHD\u2010free and relapse\u2010free survival (HR,\u00a01.29;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.012). The combination of PTCy and ATG, however, led to significantly reduced rates of grade 2\u20134 (HR, 0.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0003) and grade 3\u20134 (HR, 0.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.018) acute GVHD and did not affect any transplant outcomes compared to PTCy without ATG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The authors conclude that ATG alone is a less effective prophylaxis strategy compared to PTCy, however, the combination of PTCy and ATG is superior to either monotherapy. They propose that this combination could be considered a potential new standard of care for GVHD prophylaxis in haplo\u2010SCT for AML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.35365","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:54:30Z","timestamp":1715954070000},"page":"3123-3136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Posttransplant cyclophosphamide versus anti\u2010thymocyte globulin versus combination for graft\u2010versus\u2010host disease prevention in haploidentical transplantation for adult acute myeloid leukemia: A report from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0243-4040","authenticated-orcid":false,"given":"Abdul\u2010Hamid","family":"Bazarbachi","sequence":"first","affiliation":[{"name":"EBMT Paris study office\/CEREST\u2010TC  Paris France"},{"name":"Department of Hematology Saint Antoine Hospital  Paris France"},{"name":"INSERM UMR 938 Sorbonne University  Paris France"},{"name":"Division of Hematology\/Oncology Columbia University Irving Medical Center\/New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"EBMT Paris study office\/CEREST\u2010TC  Paris France"},{"name":"Department of Hematology Saint Antoine Hospital  Paris France"},{"name":"INSERM UMR 938 Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Raiola","sequence":"additional","affiliation":[{"name":"Hematology and Cellular Therapy Unit IRCCS Ospedale Policlinico San Martino  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Transplantation and Cellular Immunotherapy Program Department of Hematology Institut Paoli Calmettes MSC Lab Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Arcese","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit \u201cTor Vergata\u201d University of Rome Policlinico Universitario Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Santarone","sequence":"additional","affiliation":[{"name":"Dipartimento Oncologico Ematologico Terapia Intensiva Ematologica Ospedale Civile  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yener","family":"Koc","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit Medicana International Hospital Istanbul  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bramanti","sequence":"additional","affiliation":[{"name":"Transplantation Unit Department of Oncology and Haematology Istituto Clinico Humanitas  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kulagin","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute Pavlov University  St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Kwon","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Trasplante de Medula Osea Hospital Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sica","sequence":"additional","affiliation":[{"name":"Universita Cattolica S. 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