{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:27:59Z","timestamp":1785680879741,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:00:00Z","timestamp":1717286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Central nervous system hemangioblastomas are the most prevalent manifestation of von Hippel\u2010Lindau (VHL) disease and remain the main cause of mortality. Surgical resection is the primary treatment strategy, but is not always possible, and should be used as restrictively as possible. There is an unmet need for less invasive treatment strategies, such as targeted therapy. Expression of somatostatin receptor 2A (SSTR2A) in VHL\u2010related hemangioblastomas has been described earlier, but the extent of expression in a larger population has yet to be determined. The authors hypothesize that a substantial subset of VHL\u2010related hemangioblastomas show SSTR2A expression, which may serve as a potential new treatment target.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were surgically treated for a VHL\u2010related hemangioblastoma from 1990 until 2021 at the UMC Utrecht were included. Clinical data was derived from a clinical database. Tissue samples were histopathologically examined with use of hematoxylin and eosin staining, and immunohistochemical analysis of SSTR2A expression was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three tissue samples were obtained from 26 patients. Nine showed strong positivity for SSTR2A expression, whereas 13 showed moderate and 15 sparse expression. Three samples showed no expression of SSTR2A. The distribution showed right\u2010skewedness favoring a strong expression. SSTR2A expression colocalized with endothelial markers and not with stromal cells. Additionally, within\u2010patient variability for SSTR2A expression was described in 14 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SSTR2A is expressed in varying degrees in the majority of VHL\u2010related hemangioblastomas. Future treatment with somatostatin analogues or even peptide receptor radionuclide treatment may be considered for SSTR2A\u2010positive cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35418","type":"journal-article","created":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T13:44:15Z","timestamp":1717335855000},"page":"3473-3479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Somatostatin receptor 2A expression in von Hippel\u2010Lindau\u2013related hemangioblastomas"],"prefix":"10.1002","volume":"130","author":[{"given":"Saya","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Endocrine Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Muhlebner","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom J.","family":"Snijders","sequence":"additional","affiliation":[{"name":"Department of Neurology UMC Utrecht Brain Center University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy W.","family":"de Leng","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Seute","sequence":"additional","affiliation":[{"name":"Department of Neurology UMC Utrecht Brain Center University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-9746","authenticated-orcid":false,"given":"Rachel S.","family":"van Leeuwaarde","sequence":"additional","affiliation":[{"name":"Department of Endocrine Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(03)13643\u20104"},{"key":"e_1_2_9_3_1","unstructured":"vanLeeuwaardeRS AhmadS vanNesselrooijB ZandeeW GilesRH.Von Hippel\u2010Lindau Syndrome; GeneReviews\u00ae [Internet].University of Washington Seattle; 2024:1993\u20102024."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.1.0082"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15586\/jkcvhl.2017.90"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40822"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.11.023"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13139\u2010022\u201000761\u20107"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001314"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3181662bf9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3181fef14a"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13139\u2010012\u20100133\u20100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000486"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001315"},{"issue":"11","key":"e_1_2_9_15_1","first-page":"5","article-title":"Physiology of somatostatin receptors","volume":"28","author":"Guillermet\u2010Guibert J","year":"2005","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31815f394a"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000700"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.51215"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1881"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP300817"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080742"},{"key":"e_1_2_9_22_1","unstructured":"National Cancer Institute.Belzutifan Approved to Treat Tumors Linked to Inherited Disorder VHL.2022. 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