{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:42:10Z","timestamp":1768423330274,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Environmental toxicants may impact survival in children with cancer, but the literature investigating these associations remains limited. Because oil and gas developments emit several hazardous air pollutants, the authors evaluated the relationship between residential proximity to oil or gas development and survival across 21 different pediatric cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Texas Cancer Registry had 29,730 children (\u226419 years old) diagnosed with a primary cancer between 1995 to 2017. Geocoded data were available for 285,266 active oil or gas wells and 109,965 horizontal wells. The authors calculated whether each case lived within 1000 m (yes\/no) from each type of oil or gas development. Survival analyses were conducted using Cox regression, adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14.2% of cases lived within 1000 m of an oil or gas well or horizontal well. Living within 1000 m of an oil or gas well was associated with risk of mortality in cases with acute myeloid leukemia (AML) (adjusted hazard ratio [aHR], 1.36; 95% confidence interval [CI], 1.01\u20131.84) and hepatoblastoma (aHR, 2.13; 95% CI, 1.03\u20134.39). An inverse association was observed with Ewing sarcoma (aHR, 0.35; 95% CI, 0.13\u20130.95). No associations were observed with horizontal well. There was evidence of a dose\u2010response effect in children with AML or hepatoblastoma and residential proximity to oil or gas wells. In general, the magnitude of association increased with decreasing distance and with higher number of wells across the three distances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Residential proximity to oil or gas wells at diagnosis is associated with the risk of mortality in children with AML or hepatoblastoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35449","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T14:17:15Z","timestamp":1719325035000},"page":"3724-3733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Residential proximity to oil and gas developments and childhood cancer survival"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8498-0020","authenticated-orcid":false,"given":"Thanh T.","family":"Hoang","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Dan L. Duncan Comprehensive Cancer Center Baylor College of Medicine  Houston Texas USA"},{"name":"Cancer and Hematology Center Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rutu A.","family":"Rathod","sequence":"additional","affiliation":[{"name":"Peter O\u2019Donnell Jr. School of Public Health University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-6447","authenticated-orcid":false,"given":"Omar","family":"Rosales","sequence":"additional","affiliation":[{"name":"Epidemiology and Population Sciences Section Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-1056","authenticated-orcid":false,"given":"Maria I.","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy M.","family":"Schraw","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Dan L. 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Duncan Comprehensive Cancer Center Baylor College of Medicine  Houston Texas USA"},{"name":"Cancer and Hematology Center Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abiodun O.","family":"Oluyomi","sequence":"additional","affiliation":[{"name":"Epidemiology and Population Sciences Section Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Dan L. 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