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Recent advancements in phase 3 clinical trials have broadened current understanding of ADCs, especially trastuzumab deruxtecan, in treating other HER2\u2010expressing malignancies. This expansion of knowledge has led to the US Food and Drug Administration's approval of trastuzumab deruxtecan for HER2\u2010positive and HER2\u2010low breast cancer, HER2\u2010positive gastric cancer, and HER2\u2010mutant nonsmall cell lung cancer. Concurrent with the increasing use of ADCs in oncology, there is growing concern among health care professionals regarding the rise in the incidence of interstitial lung disease or pneumonitis (ILD\/p), which is associated with anti\u2010HER2 ADC therapy. Studies on anti\u2010HER2 ADCs have reported varying ILD\/p mortality rates. Consequently, it is crucial to establish guidelines for the diagnosis and management of ILD\/p in patients receiving anti\u2010HER2 ADC therapy. 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This report presents the expert panel's opinions and recommendations, which are intended to guide the management of ILD\/p induced by anti\u2010HER2 ADC therapy in clinical practice.<\/jats:p>","DOI":"10.1002\/cncr.35475","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T06:03:30Z","timestamp":1722578610000},"page":"3054-3066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical best practices in interdisciplinary management of human epidermal growth factor receptor 2 antibody\u2010drug conjugates\u2013induced interstitial lung disease\/pneumonitis: An expert consensus in China"],"prefix":"10.1002","volume":"130","author":[{"given":"Chunwei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital)  Hangzhou Zhejiang China"},{"name":"Institute of Cancer and Basic 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