{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:39:22Z","timestamp":1770061162774,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>PDGFRB<\/jats:italic> fusions in acute lymphoblastic leukemia (ALL) is rare. The authors identified 28 pediatric <jats:italic>PDGFRB<\/jats:italic>\u2010positive ALL. They analyzed the features, outcomes, and prognostic factors of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, retrospective study included 6457 pediatric patients with newly diagnosed PDGFRB fusion ALL according to the CCCG\u2010ALL\u20102015 and CCCG\u2010ALL\u20102020 protocols from April 2015 to April 2022 in 20 hospitals in China. Of these patients, 3451 were screened for PDGFRB fusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pediatric <jats:italic>PDGFRB<\/jats:italic>\u2010positive ALL accounted for only 0.8% of the 3451 cases tested for PDGFRB. These patients included 21 males and seven females and 24 B\u2010ALL and 4 T\u2010ALL; the median age was 10 years; and the median leukocyte count was 29.8 \u00d7 10<jats:sup>9<\/jats:sup>\/L at baseline. Only one patient had eosinophilia. Three patients had an IKZF1 deletion, three had chromosome 5q31\u201033 abnormalities, and one suffered from a complex karyotype. The 3\u2010year event\u2010free survival (EFS), overall survival (OS), and cumulative incidence of relapse (CIR) were 33.1%, 65.5%, and 32.1%, respectively, with a median follow\u2010up of 25.5 months. Twenty patients were treated with chemotherapy plus tyrosine\u2010kinase inhibitors (TKIs) and eight were treated without TKI. Complete remission (CR) rates of them were 90.0% and 63.6%, respectively, but no differences in EFS, OS, or CIR. Univariate analyses showed patients with IKZF1 deletion or measurable residual disease (MRD) \u22650.01% after induction had inferior outcomes (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pediatric PDGFRB\u2010positive ALL has a poor outcome associated with high\u2010risk features. Chemotherapy plus TKIs can improve the CR rate, providing an opportunity for lower MRD levels and transplantation. MRD \u22650.01% was a powerful adverse prognostic factor, and stratified treatment based on MRD may improve survival for these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Pediatric acute lymphoblastic leukemia patients with <jats:italic>PDGFRB<\/jats:italic> fusions are associated with high\u2010risk clinical features such as older age, high white blood cell count at diagnosis, high measurable residual disease after induction therapy, and increased risk of leukemia relapse.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Chemotherapy plus tyrosine\u2010kinase inhibitors can improve the complete remission rate and provide an opportunity for lower measurable residual disease (MRD) levels and transplantation for pediatric <jats:italic>PDGFRB<\/jats:italic>\u2010positive acute lymphoblastic leukemia (ALL) patients.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The MRD level was also a powerful prognostic factor for pediatric <jats:italic>PDGFRB<\/jats:italic>\u2010positive ALL patients.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35481","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T05:24:55Z","timestamp":1723526695000},"page":"3902-3912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Delineation of features, responses, outcomes, and prognostic factors in pediatric <i>PDGFRB<\/i>\u2010positive acute lymphoblastic leukemia patients: A retrospective multicenter study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4972-2317","authenticated-orcid":false,"given":"Xiaoyan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology KunMing Children\u2019s Hospital  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Guangzhou Women and Children\u2019s Medical Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Anhui Medical University Second Affiliated Hospital  Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Union Hospital of Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Key Laboratory of Pediatric Hematology &amp; Oncology of China Ministry of Health  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children\u2019s Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children\u2019s Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changcheng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Jiangxi Provincial Children\u2019s Hospital  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children\u2019s Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children\u2019s Hospital Affiliated to Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex W. 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