{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:11:32Z","timestamp":1787663492094,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The authors report the prospective evaluation of reduced dose alkylator chemotherapy combined with radiotherapy for European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) standard risk nonalveolar rhabdomyosarcoma (NA\u2010RMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Localized node negative Intergroup Rhabdomyosarcoma Study (IRS) II\/III NA\u2010RMS at favorable sites (subgroup C), &lt;25 years old, received five cycles of ifosfamide, vincristine, and dactinomycin (IVA) chemotherapy (30 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ifosfamide) and four cycles of vincristine and dactinomycin (if receiving radiotherapy), or nine cycles of IVA (54 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ifosfamide) \u00b1 radiotherapy. Delayed primary tumor excision was considered for IRS III tumors. The primary end points were event\u2010free survival (EFS) and overall survival (OS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From October 2005 to December 2016, 359 evaluable patients were recruited: orbit, 164 (45.7%); head and neck nonparameningeal, 77 (21.4%); and genitourinary non\u2013bladder\/prostate, 118 (32.9%). EFS and OS were 77.4% (95% confidence interval [CI], 72.5\u201381.6) and 93.5% (95% CI, 90.1\u201395.8), respectively. Lower dose alkylator chemotherapy and radiotherapy achieved 5\u2010year OS of 93.7% but the difference with higher dose alkylator chemotherapy +\/\u2010 radiotherapy was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.8003). Adjuvant radiotherapy improved EFS with 5\u2010year estimates of 84.7% versus 65.2% for nonirradiated (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001), but not OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.9298). Omitting radiotherapy for orbital tumors reduced OS (5\u2010year was 87.1% vs. 97.3% for irradiated,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0257). Following R0 resection (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a060), radiotherapy did not significantly improve EFS or OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Radiotherapy for local tumor control allows for reduction of cumulative dose of alkylators in EpSSG standard risk subgroup C RMS patients. The omission of radiotherapy did not affect OS in all patients except those with orbital RMS and was associated with inferior EFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.35497","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T13:31:38Z","timestamp":1722000698000},"page":"4071-4084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6820-8578","authenticated-orcid":false,"given":"Henry C.","family":"Mandeville","sequence":"first","affiliation":[{"name":"The Royal Marsden Hospital and The Institute of Cancer Research  Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4462-5523","authenticated-orcid":false,"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[{"name":"Hematology Oncology Division Department of Women\u2019s and Children\u2019s Health University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0296-5207","authenticated-orcid":false,"given":"Veronique","family":"Minard\u2010Colin","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology INSERM U1015 Gustave Roussy Universit\u00e9 Paris\u2010Saclay  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Alaggio","sequence":"additional","affiliation":[{"name":"Pathology Unit Department of Laboratories Bambino Gesu Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Ben\u2010Arush","sequence":"additional","affiliation":[{"name":"Ruth Rappaport Children's Hospital Rambam Medical Center Joan and Sanford Weill Pediatric Hematology Oncology and Bone Marrow Transplantation Division  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Chargari","sequence":"additional","affiliation":[{"name":"Radiation Oncology Gustave Roussy Cancer Campus  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Coppadoro","sequence":"additional","affiliation":[{"name":"Hematology Oncology Division Department of Women\u2019s and Children\u2019s Health University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Craigie","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Royal Manchester Children's Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Devalck","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire des Enfants Reine Fabiola ULB  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Ferman","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department National Cancer Institute  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4724-0517","authenticated-orcid":false,"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Unit Fondazione IRCCS Istituto Nazionale Tumori  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Glosli","sequence":"additional","affiliation":[{"name":"Centre for Rare Disorders Division of Paediatric and Adolescent Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Hladun","family":"Alvaro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Haematology Hospital Universitari Vall d\u2019Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-056X","authenticated-orcid":false,"given":"Marinka","family":"Hol","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mudry","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department University Hospital Brno and Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-139X","authenticated-orcid":false,"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[{"name":"SIREDO Oncology Center Institut Curie PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Ramos","family":"Albiac","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Hospital Universitari Vall d\u2019Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes H. M.","family":"Merks","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriel E. M.","family":"Jenney","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital for Wales Heath Park  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.05.016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959\u20108049(01)00007\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100051\u20102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23079"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11285"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.3287"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.130"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19921115)70:10<2557::aid\u2010cncr2820701027>3.0.co;2\u20108"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014\u20100475\u2010OA"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.1.197"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.3287"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.130"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27096"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/PBC.21702"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)31610\u20100"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.04.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.12.025"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70408\u20105"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.9694"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.003"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28701"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24547"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.11.011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.12.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33275"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:36:03Z","timestamp":1760276163000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":25,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/cncr.35497"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35497","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,26]]},"assertion":[{"value":"2023-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}