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Several clinical trials are investigating InO in combination with low\u2010intensity chemotherapy or other anti\u2010ALL\u2013targeted therapies in the salvage and frontline settings, notably in older adults who often cannot tolerate intensive chemotherapy and tend to have higher\u2010risk disease. InO is also increasingly used to bridge patients to hematopoietic stem cell transplantation (HSCT), in sequence with chimeric antigen receptor T\u2010cell therapy, to eliminate measurable residual disease and to prevent post\u2010HSCT relapse. Veno\u2010occlusive disease\/sinusoidal obstruction syndrome is a potential complication of InO treatment, particularly when followed by HSCT. Herein, the authors review the historical development and current status of InO, strategies for mitigating the risk of InO\u2010related veno\u2010occlusive disease\/sinusoidal obstruction syndrome, and future directions for InO research and clinical use.<\/jats:p>","DOI":"10.1002\/cncr.35505","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T09:40:59Z","timestamp":1722591659000},"page":"3631-3646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Inotuzumab ozogamicin in adult acute lymphoblastic leukemia: Development, current status, and future directions"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-3307","authenticated-orcid":false,"given":"Hagop M.","family":"Kantarjian","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas 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