{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:44:24Z","timestamp":1779317064009,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["21378"],"award-info":[{"award-number":["21378"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2022A4WZFC"],"award-info":[{"award-number":["2022A4WZFC"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pooled analysis of seven case\u2010control studies within the Stomach Cancer Pooling Project, including 3220 cases and 9752 controls, was conducted. Two\u2010stage modeling analyses were used to estimate the association between aspirin and statin use and GC after adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled odds ratio (OR) of GC for aspirin users versus nonusers was 0.72 (95% confidence interval [CI], 0.54\u20130.95). The protective effect of aspirin appeared stronger in individuals without a GC family history (OR, 0.60; 95% CI, 0.37\u20130.95), albeit with borderline heterogeneity between those with and without a family history (<jats:italic>p<\/jats:italic> = .064). The OR of GC decreased with increasing duration of aspirin use, with an OR of 0.41 (95% CI, 0.18\u20130.95) for durations of \u226515 years. An inverse, nonsignificant association with the risk of GC was observed for the use of statins alone (OR, 0.79; 95% CI, 0.52\u20131.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that aspirin use, particularly long\u2010term use, is associated with a reduced risk of GC, whereas a similar association was not observed with statins, possibly because of the low frequency of use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35510","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T03:00:40Z","timestamp":1723950040000},"page":"4276-4286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Aspirin but not statins is inversely related to gastric cancer with a duration\u2013risk effect: Results from the Stomach Cancer Pooling Project Consortium"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5013-0733","authenticated-orcid":false,"given":"Roberta","family":"Pastorino","sequence":"first","affiliation":[{"name":"Section of Hygiene University Department of Health Sciences and Public Health Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario A. 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