{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:26:46Z","timestamp":1778084806368,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The care of adolescents and young adults (AYAs) with bone sarcomas involves unique challenges. The objectives of this study were to identify challenges and evaluate long\u2010term outcomes of these patients from India who received treatment with novel protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study included AYA patients (aged 15\u201339 years) with osteosarcoma and Ewing sarcoma (ES), who were treated uniformly at the authors' institute using unique protocols (<jats:italic>OGS\u201012<\/jats:italic> and <jats:italic>EFT\u20102001<\/jats:italic>) from 2011 to 2021 and from 2013 to 2018, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohorts included 688 of 748 (91.9%) treatment\u2010naive AYA patients with osteosarcoma and 126 of 142 (88.7%) treatment\u2010naive AYA patients with ES. Among 481 of 561 patients (85.7%) who had nonmetastatic osteosarcoma treated according to protocol, at a median follow\u2010up of 59.7 months, the 5\u2010year event\u2010free survival (5\u2010EFS) rate was 58.6% (95% confidence interval, 54.1%\u201363.5%) and for 142 patients (20.6%) who had metastatic osteosarcoma, the 5\u2010EFS rate was 18.7%. The 5\u2010EFS rate was 66.4% and 21.9% for 104 patients (73%) with nonmetastatic ES and 38 patients (27%) with metastatic ES, respectively. Treatment\u2010naive patients had better outcomes, similar to compliance in the form of protocol completion (hazard ratio, 1.93 [<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0043] and 2.66 [<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001], respectively. Only 230 of 377 (61.0%) male patients and 10 of 134 (7.4%) female patients reached out to fertility specialists. In addition, 17 of 161 (10.6%) eligible male survivors and 14 of 61 (22.9%) eligible female survivors got married posttreatment. Furthermore, 14 of 17 (82.4%) males and 14 of 14 (100%) females conceived. Among 311 patients who were working or attending school during diagnosis, greater than 90% had interruptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Homogenous treatment with the OGS\u201012 and EFT\u20102001 protocols resulted in internationally comparable long\u2010term outcomes in the cohorts with nonmetastatic and metastatic AYA bone sarcomas. Treatment compliance, timely referral to sarcoma reference centers (avoiding prior inadvertent treatment), and streamlining fertility\u2010preservation practices constitute unmet needs that demand prioritization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35547","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T06:31:14Z","timestamp":1726727474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ten\u2010year follow\u2010up of outcomes, patterns of care, and psychosocial burden in adolescent and young adult patients with bone sarcomas from a large cohort in a low\u2010income and middle\u2010income country"],"prefix":"10.1002","volume":"131","author":[{"given":"Jyoti","family":"Bajpai","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Tata Memorial Center Homi Bhabha National Institute  Mumbai 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