{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:31:05Z","timestamp":1760315465676,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Many childhood cancer survivors are at risk for cardiovascular disease and stroke. The North American Children's Oncology Group long\u2010term follow\u2010up guidelines recommend carotid ultrasound in cancer survivors 10 years after neck radiation therapy (RT) \u226540 Gy. The use of carotid ultrasound in this population has not been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Survivors of childhood cancer diagnosed 1970\u20101999 (<jats:italic>N<\/jats:italic>\u00a0=\u00a08693) and siblings (<jats:italic>N<\/jats:italic>\u00a0=\u00a01989) enrolled in the Childhood Cancer Survivor Study were asked if they had ever had a carotid ultrasound. Prevalence of carotid ultrasound was evaluated. Prevalence ratios (PR) and 95% confidence intervals (CIs) were evaluated in multivariate Poisson regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among participants with no reported cardiovascular condition, prevalence of carotid ultrasound among survivors with RT\u00a0\u226540 Gy to the neck (<jats:italic>N<\/jats:italic>\u00a0=\u00a0172) was 29.7% (95% CI, 22.5\u201336.8), significantly higher than those with &lt;40 Gy (prevalence 10.7%; 95% CI, 9.9%\u201311.4%). Siblings without a cardiovascular condition (<jats:italic>N<\/jats:italic>\u00a0=\u00a01621) had the lowest prevalence of carotid ultrasound (4.7%; 95% CI, 3.6%\u20135.7%). In a multivariable models among survivors with no reported cardiovascular condition and RT\u00a0\u226540 Gy to the neck, those who were over age 50 (vs. 18\u201349) at follow\u2010up (PR\u00a0=\u00a01.82; 95% CI, 1.09\u20133.05), with a history of seeing a cancer specialist in the last 2 years (PR\u00a0=\u00a02.58; 95% CI, 1.53\u20134.33), or having a colonoscopy (PR\u00a0=\u00a02.02; 95% CI, 1.17\u20133.48) or echocardiogram (PR\u00a0=\u00a06.42; 95% CI, 1.54\u201326.85) were more likely to have had a carotid ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Many survivors do not undergo carotid ultrasound despite meeting existing guidelines. Health care delivery features such as having seen a cancer specialist or having other testing are relevant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35591","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T12:13:50Z","timestamp":1728562430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of carotid ultrasound screening in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8956-3947","authenticated-orcid":false,"given":"Yolanda","family":"Bryce","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian A.","family":"Whitton","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla L.","family":"Stratton","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy M.","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Chow","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Seattle Children\u2019s Hospital University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Armstrong","sequence":"additional","affiliation":[{"name":"St. Jude Children\u2019s Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Weil","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital Harvard Medical School Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Dieffenbach","sequence":"additional","affiliation":[{"name":"Scripps Health  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M.","family":"Howell","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Oeffinger","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-0871","authenticated-orcid":false,"given":"Paul C.","family":"Nathan","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-5210","authenticated-orcid":false,"given":"Emily S.","family":"Tonorezos","sequence":"additional","affiliation":[{"name":"National Cancer Institute  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"volume-title":"Cancer Treatment & Survivorship Facts & Figures 2019\u20102021","year":"2019","key":"e_1_2_9_2_1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.15.107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000001951"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.07.2884"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.03.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw211"},{"key":"e_1_2_9_8_1","unstructured":"Group; CsO: Long\u2010Term Follow\u2010Up Guidelines for Survivors of Childhood Adolescent and Young Adult Cancers Version 5.0 2018. Accessed June 10 2023.http:\/\/www.survivorshipguidelines.org\/pdf\/2018\/cog_ltfu_guidelines_v5.pdf"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/m14\u20100530"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.556068"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.4920"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20364"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.3339"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idm.2019.12.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01825"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010014\u20100160\u20105"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.07.031"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e31820d8c98"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.3920"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.epi\u201017\u20100510"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.119.041403"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000025"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00547"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32568"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010021\u201001060\u20104"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475\u20106773.12282"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9976"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.35591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:58:44Z","timestamp":1760266724000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.35591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/cncr.35591"],"URL":"https:\/\/doi.org\/10.1002\/cncr.35591","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"2023-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35591"}}