{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:07:28Z","timestamp":1792638448407,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgen\u2010deprivation therapy (ADT) remains a cornerstone in treatment for patients with advanced prostate cancer. ADT is associated with several adverse effects, including osteoporosis, metabolic syndrome, and cardiovascular events, leading to guidelines recommending routine testing to monitor for these toxicities. There is a lack of data assessing adherence to these recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors conducted a retrospective cohort study using administrative data from Ontario, Canada between 2008 and 2021. They identified all older men (aged 65 years and older) who received ADT for prostate cancer using comprehensive provincial health databases. The primary outcomes were the use of testing for lipids, dysglycemia (glucose), bone health serum, and bone density between 6 weeks before and 1 year after the initiation of ADT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 29,097 patients were examined, of whom 52.8% were prescribed ADT by urologists, 37.9% were prescribed ADT by radiation oncologists, 2.8% were prescribed ADT by medical oncologists, and 2.4% were prescribed ADT by other physicians. Adherence to guidelines was low: only 21.3% of patients received a bone density scan, 41.2% underwent bone health\u2013related serum tests, 51.3% completed a lipid profile, and 65.9% underwent dysglycemia testing within 1 year of diagnosis. Overall, only 11.9% of patients received all of the recommended investigations. Adherence to testing did not appear to improve over time (2008\u20132021) or with guideline publication. Patient (age) and physician (specialty) factors had important associations with adherence to testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most patients receiving ADT for prostate cancer do not receive recommended testing to monitor for treatment\u2010related toxicity. Further study is required to address barriers to therapeutic monitoring of men on ADT and to reduce treatment\u2010associated adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35606","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T04:00:27Z","timestamp":1728792027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metabolic, cardiac, and bone health testing in patients with prostate cancer on androgen\u2010deprivation therapy: A population\u2010based assessment of adherence to therapeutic monitoring guidelines"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-8048","authenticated-orcid":false,"given":"Ahmad","family":"Mousa","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u2010Dan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aly\u2010Khan","family":"Lalani","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Juravinski Cancer Center McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Satkunasivam","sequence":"additional","affiliation":[{"name":"Department of Urology Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khatereh","family":"Aminoltejari","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Princess Margaret Cancer Center University of Toronto  Toronto Ontario 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-3455","authenticated-orcid":false,"given":"Shawn","family":"Malone","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Department of Radiology The Ottawa Hospital Cancer Center University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kokorovic","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke T.","family":"Lavall\u00e9e","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery The Ottawa Hospital University of Ottawa  Ottawa Ontario 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