{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:27:36Z","timestamp":1788560856711,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Soft tissue sarcoma (STS) is one of the most frequently diagnosed cancers among men younger than age 30 years and a leading cause of cancer death in men younger than age 40 years. The military may be more exposed to STS risk factors and have generally better health and health care access than the general population, which may relate to lower cancer risk and\/or early detection. This study compared STS incidence between servicemen and men in the general U.S. population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were from the Department of Defense\u2019s Automated Central Tumor Registry (ACTUR) and the National Cancer Institute\u2019s Surveillance, Epidemiology, and End Results (SEER) program. Subjects were active\u2010duty servicemen in ACTUR and men in SEER aged 18\u201359 years diagnosed with STS from 1990 to 2013. Age\u2010adjusted rates, incidence rate ratios (IRR), and 95% CIs were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>STS incidence rates were lower in ACTUR than SEER overall (IRR\u00a0=\u00a00.86 [0.78\u20100.93]), for 18\u2010 to 39\u2010year\u2010old men (IRR\u00a0=\u00a00.78 [0.70\u20100.86]), by race (White: IRR\u00a0=\u00a00.85 [0.77\u20100.95]; Black: IRR\u00a0=\u00a00.77 [0.63\u20100.94]), for sites other than skin\/connective\/soft tissue (IRR\u00a0=\u00a00.49 [0.37\u20100.63]), other specified histologies (IRR\u00a0=\u00a00.84 [0.71\u20100.98]), and unspecified histology (IRR\u00a0=\u00a00.57 [0.38\u20100.82]). Rates were lower in ACTUR for regional (IRR\u00a0=\u00a00.37 [0.28\u20100.47]) and distant metastases (IRR\u00a0=\u00a00.58 [0.43\u20100.76]), even when race and age stratified. However, rates were higher in ACTUR for 40\u2010 to 59\u2010year\u2010old men (IRR\u00a0=\u00a01.25 [1.04\u20101.48]) and localized tumors (IRR\u00a0=\u00a01.16 [1.04\u20101.29]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lower STS rates among servicemen may relate to better health and early detection and treatment of STS\u2010associated conditions within the military health system, which provides universal care. Higher rates among 40\u2010 to 59\u2010year\u2010old servicemen may result from greater cumulative military\u2010related exposures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35607","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T03:02:13Z","timestamp":1733713333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence rates of soft tissue sarcoma among U.S. military servicemen: Comparison with the rates in the general U.S. population"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-8232","authenticated-orcid":false,"given":"Julie A.","family":"Bytnar","sequence":"first","affiliation":[{"name":"Murtha Cancer Center Research Program Department of Surgery Uniformed Services University of the Health Sciences  Bethesda Maryland USA"},{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-1253","authenticated-orcid":false,"given":"Ashley B.","family":"Anderson","sequence":"additional","affiliation":[{"name":"John P. Murtha Cancer Center Walter Reed National Military Medical Center  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin K.","family":"Potter","sequence":"additional","affiliation":[{"name":"John P. Murtha Cancer Center Walter Reed National Military Medical Center  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig D.","family":"Shriver","sequence":"additional","affiliation":[{"name":"Murtha Cancer Center Research Program Department of Surgery Uniformed Services University of the Health Sciences  Bethesda Maryland USA"},{"name":"John P. Murtha Cancer Center Walter Reed National Military Medical Center  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangmin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Murtha Cancer Center Research Program Department of Surgery Uniformed Services University of the Health Sciences  Bethesda Maryland USA"},{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.  Bethesda Maryland USA"},{"name":"Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270\u2010019\u201002259\u2010w"},{"key":"e_1_2_11_3_1","unstructured":"American Cancer Society.Cancer facts & figures 2020 special section: Cancer in adolescents and young adults.2020."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2023.0019"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2016.05.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.L.00546"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00134"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896919848495"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics3040499"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7791"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547\u2010018\u20100882\u20107"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/hp.0000000000000032"},{"key":"e_1_2_11_13_1","volume-title":"Camp Lejeune, North Carolina","author":"Agency for Toxic Substances and Disease Registry"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860902913546"},{"key":"e_1_2_11_15_1","first-page":"68","volume-title":"Evaluation of postdeployment cancers among active duty military personnel","author":"Sharkey JM","year":"2015"},{"key":"e_1_2_11_16_1","unstructured":"U.S. Department of Veterans Affairs.Veterans' diseases associated with Agent Orange. 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