{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:23Z","timestamp":1787169683136,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The omission of axillary lymph node dissection (ALND) remains controversial for patients with residual axillary disease after neoadjuvant chemotherapy (NAC), regardless of the residual burden. This study evaluated the oncologic safety and factors associated with outcomes in patients with residual axillary disease. These patients were treated solely with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD), without ALND, after NAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A joint analysis of two different multicenter cohorts\u2014the retrospective cohort registry MF18\u201002 and the prospective observational cohort registry MF18\u201003 (NCT04250129)\u2014was conducted between January 2004 and August 2022. All patients received regional nodal irradiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five hundred and one patients with cT1\u20104, N1\u20103M0 disease who achieved a complete clinical response to NAC underwent either SLNB alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0353) or TAD alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0148). At a median follow\u2010up of 42 months, axillary and locoregional recurrence rates were 0.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02) and 0.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04). No significant difference was found in disease\u2010free survival (DFS) and disease\u2010specific survival (DSS) rates between patients undergoing TAD alone versus SLNB alone, those with breast positive versus negative pathologic complete response, SLN methodology, total metastatic LN\u00a0of one versus \u22652, or metastasis types as isolated tumor cells with micrometastases versus macrometastases. In the multivariate analysis, patients with nonluminal pathology were more likely to have a worse DFS and DSS, respectively, without an increased axillary recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The omission of ALND can be safely considered for patients who achieve a complete clinical response after NAC, even if residual disease is detected by pathologic examination. Provided that adjuvant radiotherapy is administered, neither the SLNB method nor the number of excised LNs significantly affects oncologic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.35610","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T14:09:08Z","timestamp":1730297348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Combined analysis of the MF18\u201002\/MF18\u201003 NEOSENTITURK studies: ypN\u2010positive disease does not necessitate axillary lymph node dissection in patients with breast cancer with a good response to neoadjuvant chemotherapy as long as radiotherapy is provided"],"prefix":"10.1002","volume":"131","author":[{"given":"Mahmut","family":"Muslumanoglu","sequence":"first","affiliation":[{"name":"Department of General Surgery Istanbul Faculty of Medicine Istanbul University  Istanbul 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