{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:55:45Z","timestamp":1776131745282,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>De novo chronic myeloid leukemia in blastic phase (CML\u2010BP) showing lymphoid immunophenotype mimics Philadelphia chromosome\u2013positive acute lymphoblastic leukemia (Ph\u2010positive ALL). Although upfront allogeneic hematopoietic cell transplantation (HCT) is considered in both diseases, it is not yet clear whether the transplant outcomes are also similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a registry database, the transplant outcomes between de novo CML\u2010BP and Ph\u2010positive ALL in negative\u2010minimal residual disease (MRD), positive MRD, and nonremission cohorts were compared, respectively. All of the included patients had received tyrosine kinase inhibitor therapy before HCT and underwent HCT between 2002 and 2021. Regarding Ph\u2010positive ALL, patients with p210 transcripts were excluded because there was concern that this group might include patients with de novo CML\u2010BP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although most of the outcomes were comparable, in patients with positive MRD at HCT, de novo CML\u2010BP was significantly associated with superior disease\u2010free survival (DFS) (hazard ratio [HR] 0.6, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0032), overall survival (HR 0.66, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.027), and a lower risk of relapse (HR 0.48, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0051). In subgroup analyses, BCR::ABL1 mutation status had a significant interaction with the disease (<jats:italic>p<\/jats:italic>\u00a0for interaction = .0027). De novo CML\u2010BP seemed to be associated with superior disease\u2010free survival in a BCR::ABL1 mutation\u2010positive cohort, whereas this association was not observed in a mutation\u2010negative cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Considering previous reports that showed inferior outcomes for de novo CML\u2010BP compared to Ph\u2010positive ALL, the data suggested that allogeneic HCT could overcome the poor prognosis of de novo CML\u2010BP. These findings highlight the importance of distinguishing de novo CML\u2010BP from Ph\u2010positive ALL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.35627","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:01:27Z","timestamp":1730764887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparing de novo chronic myeloid leukemia in blastic phase with Philadelphia chromosome\u2013positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4998-9078","authenticated-orcid":false,"given":"Yosuke","family":"Okada","sequence":"first","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center  Saitama 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