{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:22Z","timestamp":1786977502952,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Survival rates from childhood cancer continue to increase, with an ongoing interest in long\u2010term survivorship. Although infertility and gonadal failure are well recognized in Hodgkin lymphoma (HL) survivors, sexual dysfunction is less studied. The objective of this study was to compare the prevalence of sexual dysfunction in HL survivors with that in matched community controls.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Long\u2010term survivors of HL (\n n<\/jats:italic>\n \u00a0=\u00a0186; female, 51.61%; mean age at diagnosis. 14.41 years [range, 3.01\u201322.60 years]; current mean\u00a0\u00b1\u00a0standard deviation age, 36.73\u00a0\u00b1\u00a07.93 years) and matched community controls (\n n<\/jats:italic>\n \u00a0=\u00a0182; female, 50.55%; mean\u00a0\u00b1\u00a0standard deviation age, 36.41\u00a0\u00b1\u00a09.02 years) completed a comprehensive, in\u2010person clinical assessment, laboratory battery, and the International Index of Erectile Function or the Female Sexual Function Index questionnaire.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Male survivors had increased levels of erectile dysfunction (18.89% vs. 6.67%;\n p<\/jats:italic>\n \u00a0=\u00a0.0239) but indicated no difference in sexual desire. Female survivors had a higher prevalence of sexual dysfunction compared with female controls (46.88% vs. 15.22%;\n p<\/jats:italic>\n \u00a0<\u00a0.0001) and an increased prevalence of moderate\u2010to\u2010severe loss of sexual desire (38.04% vs. 23.26%;\n p<\/jats:italic>\n \u00a0=\u00a0.0361). Female survivors with sexual dysfunction indicated increased levels of anxiety (\n p<\/jats:italic>\n \u00a0=\u00a0.0184), depression (\n p<\/jats:italic>\n \u00a0=\u00a0.0153), and worse physical and mental health (\n p<\/jats:italic>\n \u00a0=\u00a0.0141 and\n p<\/jats:italic>\n \u00a0=\u00a0.0419, respectively). Male survivors with erectile dysfunction had higher rates of anxiety and impaired physical health (\n p<\/jats:italic>\n \u00a0=\u00a0.0147 and\n p<\/jats:italic>\n \u00a0=\u00a0.0266, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Sexual dysfunction was prevalent in this childhood and adolescent Hodgkin lymphoma survivor cohort and was associated with effects on quality of life. Health care providers must recognize the need for screening and intervention in this group to hopefully contribute to improved overall quality of life.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cncr.35637","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T02:05:28Z","timestamp":1731031528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sexual dysfunction among long\u2010term survivors of Hodgkin lymphoma"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8743-7186","authenticated-orcid":false,"given":"Emily","family":"Hanzlik","sequence":"first","affiliation":[{"name":"Pediatric Medicine Division of Neurology St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7584-2574","authenticated-orcid":false,"given":"Noah D.","family":"Sabin","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Delaney","sequence":"additional","affiliation":[{"name":"Pediatric Medicine Division of Endocrinology St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xie","sequence":"additional","affiliation":[{"name":"Biostatistics St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himani","family":"Darji","sequence":"additional","affiliation":[{"name":"Department of Quantitative Sciences Unit Stanford University Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deokumar","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Biostatistics St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Mulrooney","sequence":"additional","affiliation":[{"name":"Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USA"},{"name":"Oncology St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USA"},{"name":"Oncology St Jude Children's Research Hospital Memphis Tennessee 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