{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:51Z","timestamp":1786977531766,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myeloproliferative neoplasms represent a heterogeneous group of acquired hematopoietic stem cell diseases in which chronic inflammation is essential for both clonal evolution and thrombotic complications. The neutrophil\u2010to\u2010lymphocyte ratio (NLR), reflecting the imbalance between systemic inflammation and immunity, is emerging as a prognostic biomarker in several diseases, including hematological ones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 473 patients with essential thrombocythemia (ET), the relationship between NLR value at diagnosis and the risk of thrombotic events in the follow\u2010up, in addition to conventional clinical and biological variables, were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 78 thrombotic events were reported for an incidence rate of 1.8 \u00d7 100 patients\/year. In multivariate analysis, NLR value\u00a0\u22654 at diagnosis was associated with higher cumulative thrombotic risk (hazard ratio [HR], 2.05; 95% CI, 1.29\u20132.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0001) as well International Prognostic Score for Thrombosis in Essential Thrombosis score intermediate\u2010high (HR, 2.69; 95% CI, 1.27\u20135.72;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01) and diabetes (HR, 2.49; 95% CI, 1.23\u20133.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.010). Concerning arterial thrombotic events, in multivariate analysis, NLR value at diagnosis \u22654 was predictive for thrombosis (HR, 2.13; 95% CI, 1.31\u20134.04;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001 as well diabetes (HR, 2.44; 95% CI, 1.05\u20135.68;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.04) and hypertension (HR, 2.46; 95% CI, 1.05\u20135.68;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01). About venous thrombotic events, NLR value\u00a0\u22655 was a marker predictive for venous thrombosis (HR, 2.99; 95% CI, 2.45\u20136.48;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01) as well age &gt;60 years old (HR, 2.26; 95% CI, 1.0\u20135.10;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NLR value is a simple, cost\u2010effective, and easy\u2010to\u2010obtain inflammatory marker that can predict a diagnosis the risk of thrombosis in ET. Our results suggest that NLR value could be integrated into conventional cardiovascular risk scores, to better classify high\u2010risk patients who are candidates for cytoreductive therapy. Further larger and prospective studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.35638","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T08:55:07Z","timestamp":1731401707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neutrophil\u2010to\u2010lymphocyte ratio (NLR) at diagnosis in essential thrombocythemia: A new promising predictor of thrombotic events"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0111-1521","authenticated-orcid":false,"given":"Alessia","family":"Ripamonti","sequence":"first","affiliation":[{"name":"Division of Haematology and Bone marrow transplant Fondazione IRCCS San Gerardo Dei Tintori  Monza Italia"},{"name":"Division of Haematology Ospedale Valduce  Como Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Cavalca","sequence":"additional","affiliation":[{"name":"Division of Haematology and Bone marrow transplant Fondazione IRCCS San Gerardo Dei Tintori  Monza Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Montelisciani","sequence":"additional","affiliation":[{"name":"University of Milano\u2010Bicocca Bicocca Bioinformatics Biostatistics and Bioimaging (B4) Centre School of Medicine and Surgery University of Milano Bicocca  Monza Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Antolini","sequence":"additional","affiliation":[{"name":"University of Milano\u2010Bicocca Bicocca Bioinformatics Biostatistics and Bioimaging (B4) Centre School of Medicine and Surgery University of Milano Bicocca  Monza Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gambacorti\u2010Passerini","sequence":"additional","affiliation":[{"name":"Division of Haematology and Bone marrow transplant Fondazione IRCCS San Gerardo Dei Tintori  Monza Italia"},{"name":"Division of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Maria","family":"Elli","sequence":"additional","affiliation":[{"name":"Division of Haematology and Bone marrow transplant Fondazione IRCCS San Gerardo Dei Tintori  Monza Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic\/Dendritic Neoplasms","author":"Khoury 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